Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 221064..221824 Replicon chromosome
Accession NZ_CP100736
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NL742_RS01045 Protein ID WP_000533909.1
Coordinates 221339..221824 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3J3UQX4
Locus tag NL742_RS01040 Protein ID WP_000965888.1
Coordinates 221064..221351 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL742_RS01020 (216394) 216394..217305 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NL742_RS01025 (217315) 217315..219384 + 2070 WP_001291732.1 glycine--tRNA ligase subunit beta -
NL742_RS01030 (219846) 219846..220277 + 432 Protein_204 IS3 family transposase -
NL742_RS01035 (220419) 220419..220886 + 468 WP_000702451.1 GNAT family N-acetyltransferase -
NL742_RS01040 (221064) 221064..221351 + 288 WP_000965888.1 DUF1778 domain-containing protein Antitoxin
NL742_RS01045 (221339) 221339..221824 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NL742_RS01050 (222196) 222196..222735 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NL742_RS01055 (222910) 222910..223122 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NL742_RS01060 (223410) 223410..223700 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NL742_RS01065 (224139) 224139..224849 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NL742_RS01070 (224899) 224899..225873 - 975 WP_000804680.1 glyoxylate/hydroxypyruvate reductase GhrB -
NL742_RS01075 (226103) 226103..226765 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T251282 WP_000533909.1 NZ_CP100736:221339-221824 [Salmonella enterica subsp. enterica serovar Agona]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10978.62 Da        Isoelectric Point: 4.6811

>AT251282 WP_000965888.1 NZ_CP100736:221064-221351 [Salmonella enterica subsp. enterica serovar Agona]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRIFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3J3UQX4

References