Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 221064..221824 | Replicon | chromosome |
| Accession | NZ_CP100736 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R18.1477 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | NL742_RS01045 | Protein ID | WP_000533909.1 |
| Coordinates | 221339..221824 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A3J3UQX4 |
| Locus tag | NL742_RS01040 | Protein ID | WP_000965888.1 |
| Coordinates | 221064..221351 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL742_RS01020 (216394) | 216394..217305 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| NL742_RS01025 (217315) | 217315..219384 | + | 2070 | WP_001291732.1 | glycine--tRNA ligase subunit beta | - |
| NL742_RS01030 (219846) | 219846..220277 | + | 432 | Protein_204 | IS3 family transposase | - |
| NL742_RS01035 (220419) | 220419..220886 | + | 468 | WP_000702451.1 | GNAT family N-acetyltransferase | - |
| NL742_RS01040 (221064) | 221064..221351 | + | 288 | WP_000965888.1 | DUF1778 domain-containing protein | Antitoxin |
| NL742_RS01045 (221339) | 221339..221824 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| NL742_RS01050 (222196) | 222196..222735 | - | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| NL742_RS01055 (222910) | 222910..223122 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NL742_RS01060 (223410) | 223410..223700 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NL742_RS01065 (224139) | 224139..224849 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NL742_RS01070 (224899) | 224899..225873 | - | 975 | WP_000804680.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NL742_RS01075 (226103) | 226103..226765 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T251282 WP_000533909.1 NZ_CP100736:221339-221824 [Salmonella enterica subsp. enterica serovar Agona]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10978.62 Da Isoelectric Point: 4.6811
>AT251282 WP_000965888.1 NZ_CP100736:221064-221351 [Salmonella enterica subsp. enterica serovar Agona]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRIFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRIFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3J3UQX4 |