Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4143355..4143871 Replicon chromosome
Accession NZ_CP100732
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.1932

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NL737_RS20125 Protein ID WP_000220578.1
Coordinates 4143355..4143639 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL737_RS20130 Protein ID WP_000212724.1
Coordinates 4143629..4143871 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL737_RS20110 (4138567) 4138567..4140219 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NL737_RS20115 (4140628) 4140628..4142766 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL737_RS20120 (4142887) 4142887..4143351 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL737_RS20125 (4143355) 4143355..4143639 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL737_RS20130 (4143629) 4143629..4143871 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL737_RS20135 (4143949) 4143949..4145862 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NL737_RS20140 (4145879) 4145879..4146619 - 741 WP_000779263.1 KDGP aldolase family protein -
NL737_RS20145 (4146616) 4146616..4147734 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL737_RS20150 (4147718) 4147718..4148851 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T251272 WP_000220578.1 NZ_CP100732:c4143639-4143355 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251272 WP_000212724.1 NZ_CP100732:c4143871-4143629 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References