Detailed information of TA system TA025126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 767535..768091
• Replicon: chromosome
• Accession: NC_015172
• Organism: Syntrophobotulus glycolicus DSM 8271

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F0T186
• Locus tag: SGLY_RS04055
• Protein ID: WP_013624021.1
• Coordinates: 767535..767816 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F0T187
• Locus tag: SGLY_RS04060
• Protein ID: WP_013624022.1
• Coordinates: 767813..768091 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGLY_RS04020	763087..763632	+	546	WP_013624015.1	DUF2313 domain-containing protein	-
SGLY_RS04025	763647..765185	+	1539	WP_013624016.1	hypothetical protein	-
SGLY_RS04030	765185..765517	+	333	WP_013624017.1	hypothetical protein	-
SGLY_RS04035	765517..765654	+	138	WP_013624018.1	XkdX family protein	-
SGLY_RS18065	765879..766037	+	159	WP_013624019.1	hypothetical protein	-
SGLY_RS04040	766248..766472	+	225	Protein_779	transposase	-
SGLY_RS17385	766429..766674	+	246	Protein_780	transposase	-
SGLY_RS04045	766747..767190	+	444	WP_013624020.1	GNAT family N-acetyltransferase	-
SGLY_RS04055	767535..767816	-	282	WP_013624021.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SGLY_RS04060	767813..768091	-	279	WP_013624022.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SGLY_RS04065	768370..768789	-	420	WP_207635580.1	hypothetical protein	-
SGLY_RS04070	768894..769715	+	822	WP_013624023.1	MerR family transcriptional regulator	-
SGLY_RS04075	769948..770274	+	327	WP_013624024.1	P-II family nitrogen regulator	-
SGLY_RS04080	770302..770658	+	357	WP_013624025.1	P-II family nitrogen regulator	-
SGLY_RS04085	770747..771799	+	1053	WP_013624026.1	ABC transporter substrate-binding protein	-
SGLY_RS04090	771815..772606	+	792	WP_013624027.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-88)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10801.45 Da
• Isoelectric Point: 9.0384

>T25126 WP_013624021.1 NC_015172:c767816-767535 [Syntrophobotulus glycolicus DSM 8271]
MKLDVVWTSQFKKDYKLAMKRGQNVNLLDDIIRLLAKGVPLPETNRDHTLSGNWISHRECHIQSDWLLVYRVDNDILVLT
LARTGTHSDLFGR

Nucleotide

• Length: 282 bp

>T25126 NC_015172:c767816-767535 [Syntrophobotulus glycolicus DSM 8271]
ATGAAACTGGACGTTGTCTGGACATCCCAATTCAAGAAGGACTACAAGCTGGCGATGAAACGCGGGCAAAATGTCAATTT
GCTGGACGATATCATACGTCTGCTTGCCAAGGGCGTGCCCCTACCTGAAACCAACCGCGACCACACGCTATCCGGGAATT
GGATAAGCCATCGGGAATGTCATATTCAAAGCGATTGGCTGCTTGTGTATCGCGTGGATAATGATATTCTTGTACTGACA
CTGGCCCGTACCGGAACCCACAGCGATCTGTTTGGAAGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10344.66 Da
• Isoelectric Point: 4.8146

>AT25126 WP_013624022.1 NC_015172:c768091-767813 [Syntrophobotulus glycolicus DSM 8271]
MAGSTTNISIRMDADLKAQADTLFNELGMNLSTAFNIFVRQSLREGRIPFDVSLNQPNAETIAAMQEAERIARDPNAKRY
SDVEEALRELKR

Nucleotide

• Length: 279 bp

>AT25126 NC_015172:c768091-767813 [Syntrophobotulus glycolicus DSM 8271]
ATGGCTGGCTCCACTACCAACATCAGCATCCGCATGGATGCCGACTTGAAAGCGCAGGCTGACACGCTGTTTAACGAATT
GGGGATGAACCTCTCCACGGCGTTCAATATTTTTGTTCGCCAATCGCTTCGGGAAGGCCGGATTCCCTTTGATGTTTCGC
TCAATCAGCCCAATGCCGAAACCATTGCGGCGATGCAGGAAGCCGAACGTATTGCCCGCGACCCCAATGCGAAACGCTAC
AGCGATGTAGAGGAAGCGTTGAGGGAGCTAAAAAGATGA

Structures

Toxin

• AlphaFold DB: F0T186

Antitoxin

• AlphaFold DB: F0T187