Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4246626..4247142 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag NL731_RS20850 Protein ID WP_000220581.1
Coordinates 4246626..4246910 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL731_RS20855 Protein ID WP_000212724.1
Coordinates 4246900..4247142 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS20835 (4241837) 4241837..4243489 + 1653 WP_064047086.1 alpha,alpha-phosphotrehalase -
NL731_RS20840 (4243898) 4243898..4246036 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL731_RS20845 (4246158) 4246158..4246622 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL731_RS20850 (4246626) 4246626..4246910 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL731_RS20855 (4246900) 4246900..4247142 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL731_RS20860 (4247220) 4247220..4249133 - 1914 WP_064047085.1 BglG family transcription antiterminator -
NL731_RS20865 (4249150) 4249150..4249890 - 741 WP_064047084.1 KDGP aldolase family protein -
NL731_RS20870 (4249887) 4249887..4251005 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL731_RS20875 (4250989) 4250989..4252122 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T251252 WP_000220581.1 NZ_CP100728:c4246910-4246626 [Salmonella enterica subsp. enterica serovar Blockley]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251252 WP_000212724.1 NZ_CP100728:c4247142-4246900 [Salmonella enterica subsp. enterica serovar Blockley]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References