Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4150238..4150814 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name shpA Uniprot ID A0A627EB70
Locus tag NL731_RS20385 Protein ID WP_064047505.1
Coordinates 4150527..4150814 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag NL731_RS20380 Protein ID WP_000063143.1
Coordinates 4150238..4150540 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS20365 (4146748) 4146748..4148898 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
NL731_RS20370 (4148993) 4148993..4149196 + 204 WP_000460616.1 YbdD/YjiX family protein -
NL731_RS20375 (4149207) 4149207..4150163 + 957 WP_000187838.1 GTPase -
NL731_RS20380 (4150238) 4150238..4150540 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
NL731_RS20385 (4150527) 4150527..4150814 - 288 WP_064047505.1 BrnT family toxin Toxin
NL731_RS20390 (4150865) 4150865..4151098 - 234 WP_254520850.1 hypothetical protein -
NL731_RS20395 (4151287) 4151287..4153128 + 1842 WP_020839636.1 nuclease-related domain-containing DEAD/DEAH box helicase -
NL731_RS20400 (4153740) 4153740..4154315 + 576 WP_020839637.1 restriction endonuclease subunit S -
NL731_RS20405 (4154320) 4154320..4155573 + 1254 WP_074180616.1 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11308.83 Da        Isoelectric Point: 9.5894

>T251251 WP_064047505.1 NZ_CP100728:c4150814-4150527 [Salmonella enterica subsp. enterica serovar Blockley]
MPMEFEWDANKAKSNLRKHGVRFEDALLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT251251 WP_000063143.1 NZ_CP100728:c4150540-4150238 [Salmonella enterica subsp. enterica serovar Blockley]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A627EB70

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References