Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3547961..3548581 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL731_RS17625 Protein ID WP_001280991.1
Coordinates 3548363..3548581 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL731_RS17620 Protein ID WP_000344807.1
Coordinates 3547961..3548335 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS17610 (3543100) 3543100..3544293 + 1194 WP_001039200.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL731_RS17615 (3544316) 3544316..3547465 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL731_RS17620 (3547961) 3547961..3548335 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL731_RS17625 (3548363) 3548363..3548581 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL731_RS17630 (3548759) 3548759..3549310 + 552 WP_064047028.1 maltose O-acetyltransferase -
NL731_RS17635 (3549427) 3549427..3549897 + 471 WP_000136181.1 YlaC family protein -
NL731_RS17640 (3549953) 3549953..3550093 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL731_RS17645 (3550099) 3550099..3550359 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL731_RS17650 (3550584) 3550584..3552134 + 1551 WP_000213139.1 EAL domain-containing protein -
NL731_RS17660 (3552365) 3552365..3552754 + 390 WP_000961285.1 MGMT family protein -
NL731_RS17665 (3552809) 3552809..3553378 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251248 WP_001280991.1 NZ_CP100728:3548363-3548581 [Salmonella enterica subsp. enterica serovar Blockley]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251248 WP_000344807.1 NZ_CP100728:3547961-3548335 [Salmonella enterica subsp. enterica serovar Blockley]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References