251247

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2409487..2410009 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NL731_RS11725 Protein ID WP_000221345.1
Coordinates 2409725..2410009 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL731_RS11720 Protein ID WP_000885424.1
Coordinates 2409487..2409735 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS11690 (2405024) 2405024..2406031 - 1008 WP_000201082.1 LacI family DNA-binding transcriptional regulator -
NL731_RS11695 (2406289) 2406289..2406471 + 183 Protein_2289 hypothetical protein -
NL731_RS11700 (2406819) 2406819..2407554 + 736 Protein_2290 helix-turn-helix domain-containing protein -
NL731_RS11705 (2407610) 2407610..2408518 - 909 WP_077946216.1 hypothetical protein -
NL731_RS11710 (2408798) 2408798..2409130 - 333 WP_000253154.1 DUF1493 family protein -
NL731_RS11715 (2409120) 2409120..2409335 - 216 WP_000206207.1 hypothetical protein -
NL731_RS11720 (2409487) 2409487..2409735 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL731_RS11725 (2409725) 2409725..2410009 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL731_RS11730 (2410180) 2410180..2410569 + 390 WP_012218813.1 RidA family protein -
NL731_RS11735 (2410621) 2410621..2411700 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL731_RS11740 (2411893) 2411893..2412381 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NL731_RS11745 (2412426) 2412426..2413934 + 1509 WP_000199415.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2406292..2416791 10499
- flank IS/Tn - - 2406819..2407388 569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T251247 WP_000221345.1 NZ_CP100728:2409725-2410009 [Salmonella enterica subsp. enterica serovar Blockley]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251247 WP_000885424.1 NZ_CP100728:2409487-2409735 [Salmonella enterica subsp. enterica serovar Blockley]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References