Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1041333..1042147 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A627ECG4
Locus tag NL731_RS05020 Protein ID WP_064047347.1
Coordinates 1041333..1041860 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL731_RS05025 Protein ID WP_000855694.1
Coordinates 1041857..1042147 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS04990 (1037633) 1037633..1038031 + 399 Protein_979 cytoplasmic protein -
NL731_RS04995 (1038222) 1038222..1038461 + 240 Protein_980 hypothetical protein -
NL731_RS05000 (1038618) 1038618..1039286 + 669 WP_000445914.1 hypothetical protein -
NL731_RS05005 (1039313) 1039313..1039807 + 495 WP_000424947.1 hypothetical protein -
NL731_RS05010 (1040052) 1040052..1040708 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NL731_RS05015 (1041037) 1041037..1041260 + 224 Protein_984 IS5/IS1182 family transposase -
NL731_RS05020 (1041333) 1041333..1041860 - 528 WP_064047347.1 GNAT family N-acetyltransferase Toxin
NL731_RS05025 (1041857) 1041857..1042147 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL731_RS05030 (1042417) 1042417..1042606 - 190 Protein_987 IS3 family transposase -
NL731_RS05035 (1042847) 1042847..1043173 + 327 WP_000393302.1 hypothetical protein -
NL731_RS05040 (1043446) 1043446..1043793 - 348 WP_001669174.1 DUF1493 family protein -
NL731_RS05045 (1043778) 1043778..1044227 - 450 WP_000381612.1 membrane protein -
NL731_RS05050 (1044659) 1044659..1045102 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL731_RS05055 (1045558) 1045558..1046208 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1041084..1041260 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19171.01 Da        Isoelectric Point: 9.6420

>T251242 WP_064047347.1 NZ_CP100728:c1041860-1041333 [Salmonella enterica subsp. enterica serovar Blockley]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLWRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251242 WP_000855694.1 NZ_CP100728:c1042147-1041857 [Salmonella enterica subsp. enterica serovar Blockley]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A627ECG4

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References