Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 887183..887808 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name vapC Uniprot ID A0A5I5T1K0
Locus tag NL731_RS04330 Protein ID WP_001748684.1
Coordinates 887410..887808 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag NL731_RS04325 Protein ID WP_000557545.1
Coordinates 887183..887410 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS04295 (882196) 882196..883713 + 1518 WP_000003339.1 lysine--tRNA ligase -
NL731_RS04300 (883789) 883789..884334 - 546 WP_000134001.1 isopentenyl-diphosphate Delta-isomerase -
NL731_RS04305 (884599) 884599..885357 + 759 WP_000244328.1 amidase activator ActS -
NL731_RS04315 (885642) 885642..886448 - 807 WP_079949449.1 DUF1460 domain-containing protein -
NL731_RS04320 (886723) 886723..886974 - 252 WP_001748683.1 hypothetical protein -
NL731_RS04325 (887183) 887183..887410 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL731_RS04330 (887410) 887410..887808 + 399 WP_001748684.1 tRNA(fMet)-specific endonuclease VapC Toxin
NL731_RS04335 (888614) 888614..889150 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NL731_RS04340 (889197) 889197..889829 + 633 WP_000835265.1 YfdX family protein -
NL731_RS04345 (890548) 890548..891135 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 885642..895595 9953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14995.39 Da        Isoelectric Point: 7.7780

>T251241 WP_001748684.1 NZ_CP100728:887410-887808 [Salmonella enterica subsp. enterica serovar Blockley]
MLKFMLDTNTCIFTIKNKPEHVKERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT251241 WP_000557545.1 NZ_CP100728:887183-887410 [Salmonella enterica subsp. enterica serovar Blockley]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5T1K0

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References