Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876264..876924 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NL731_RS04265 Protein ID WP_000244756.1
Coordinates 876511..876924 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NL731_RS04260 Protein ID WP_000351186.1
Coordinates 876264..876530 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS04240 (872192) 872192..873625 - 1434 WP_064047315.1 6-phospho-beta-glucosidase BglA -
NL731_RS04245 (873784) 873784..874095 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NL731_RS04250 (874259) 874259..874918 + 660 WP_000250289.1 hemolysin III family protein -
NL731_RS04255 (875034) 875034..876014 - 981 WP_000874175.1 tRNA-modifying protein YgfZ -
NL731_RS04260 (876264) 876264..876530 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NL731_RS04265 (876511) 876511..876924 + 414 WP_000244756.1 protein YgfX Toxin
NL731_RS04270 (876977) 876977..877498 - 522 WP_001055885.1 flavodoxin FldB -
NL731_RS04275 (877611) 877611..878507 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL731_RS04280 (878531) 878531..879244 + 714 WP_064047314.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL731_RS04285 (879250) 879250..880983 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251240 WP_000244756.1 NZ_CP100728:876511-876924 [Salmonella enterica subsp. enterica serovar Blockley]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251240 WP_000351186.1 NZ_CP100728:876264-876530 [Salmonella enterica subsp. enterica serovar Blockley]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References