Detailed information of TA system TA251239

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 795562..797260
• Replicon: chromosome
• Accession: NZ_CP100728
• Organism: Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A624P0C5
• Locus tag: NL731_RS03860
• Protein ID: WP_064047460.1
• Coordinates: 795562..796491 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NL731_RS03865
• Protein ID: WP_064047459.1
• Coordinates: 796478..797260 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL731_RS03835 (790766)	790766..791644	-	879	WP_000423170.1	itaconate degradation transcriptional regulator RipR	-
NL731_RS03840 (791736)	791736..792578	+	843	WP_001112897.1	itaconate degradation C-C-lyase RipC	-
NL731_RS03845 (792602)	792602..793129	+	528	WP_001094307.1	(R)-specific enoyl-CoA hydratase RipB/Ich	-
NL731_RS03850 (793154)	793154..794479	+	1326	WP_000982337.1	itaconate CoA-transferase RipA/Ict	-
NL731_RS03855 (794544)	794544..794924	+	381	WP_000582672.1	VOC family protein	-
NL731_RS03860 (795562)	795562..796491	-	930	WP_064047460.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NL731_RS03865 (796478)	796478..797260	-	783	WP_064047459.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NL731_RS03870 (797492)	797492..798697	+	1206	WP_064047458.1	hypothetical protein	-
NL731_RS03875 (798694)	798694..799203	+	510	WP_077951488.1	hypothetical protein	-
NL731_RS03880 (799200)	799200..801176	+	1977	WP_064047456.1	hypothetical protein	-
NL731_RS03885 (801575)	801575..802036	+	462	WP_064047455.1	hypothetical protein	-
NL731_RS03890 (802033)	802033..802248	+	216	WP_064047454.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	790766..802248	11482

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-261)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 34897.19 Da
• Isoelectric Point: 6.2460

>T251239 WP_064047460.1 NZ_CP100728:c796491-795562 [Salmonella enterica subsp. enterica serovar Blockley]
MDLRDSYARQVRLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITESLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWDTARIANLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDRDRQLLLSYKQNTPDWSLYRYPEIQHLPAIRWKLRNLAVLNDKNPAKYAAAVNKLEGVLEQHF

Nucleotide

• Length: 930 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29262.65 Da
• Isoelectric Point: 8.9048

>AT251239 WP_064047459.1 NZ_CP100728:c797260-796478 [Salmonella enterica subsp. enterica serovar Blockley]
MPNYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKQQIWLALSAYVKLPGWFVAFEQFATFVTLYTSGLTVDITPFTTKLNIGDRQLVGSVPELAAYEIA
GGVPALISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNAHSYFQYLEESSIKTGLGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A624P0C5