Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 217826..218586 Replicon chromosome
Accession NZ_CP100728
Organism Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)


Gene name tacT Uniprot ID A0A624P0M6
Locus tag NL731_RS01035 Protein ID WP_064047137.1
Coordinates 218101..218586 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NL731_RS01030 Protein ID WP_000965886.1
Coordinates 217826..218113 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL731_RS01015 (213536) 213536..215605 + 2070 WP_023137713.1 glycine--tRNA ligase subunit beta -
NL731_RS01020 (215995) 215995..216393 + 399 Protein_202 IS3 family transposase -
NL731_RS01025 (216596) 216596..217630 - 1035 WP_001240754.1 CHAT domain-containing protein -
NL731_RS01030 (217826) 217826..218113 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NL731_RS01035 (218101) 218101..218586 + 486 WP_064047137.1 GNAT family N-acetyltransferase Toxin
NL731_RS01040 (218957) 218957..219496 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
NL731_RS01045 (219670) 219670..219882 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NL731_RS01050 (220170) 220170..220460 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NL731_RS01055 (220899) 220899..221609 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NL731_RS01060 (221659) 221659..222633 - 975 WP_064047136.1 glyoxylate/hydroxypyruvate reductase GhrB -
NL731_RS01065 (222852) 222852..223514 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(33-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17740.41 Da        Isoelectric Point: 10.0004

>T251237 WP_064047137.1 NZ_CP100728:218101-218586 [Salmonella enterica subsp. enterica serovar Blockley]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVYKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFNGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT251237 WP_000965886.1 NZ_CP100728:217826-218113 [Salmonella enterica subsp. enterica serovar Blockley]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A624P0M6

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References