Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 17580..18105 | Replicon | plasmid pR17.1476_64k |
Accession | NZ_CP100725 | ||
Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | I3W3D5 |
Locus tag | NL714_RS23380 | Protein ID | WP_001159863.1 |
Coordinates | 17800..18105 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | M7S5D0 |
Locus tag | NL714_RS23375 | Protein ID | WP_000813641.1 |
Coordinates | 17580..17798 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NL714_RS23345 (NL714_23345) | 13194..13580 | + | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
NL714_RS23350 (NL714_23350) | 13633..13752 | + | 120 | Protein_17 | recombinase | - |
NL714_RS23355 (NL714_23355) | 14121..15110 | - | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
NL714_RS23360 (NL714_23360) | 15604..15899 | - | 296 | Protein_19 | cytoplasmic protein | - |
NL714_RS23365 (NL714_23365) | 15911..16339 | + | 429 | Protein_20 | hypothetical protein | - |
NL714_RS23370 (NL714_23370) | 16383..16904 | - | 522 | WP_077681952.1 | hypothetical protein | - |
NL714_RS23375 (NL714_23375) | 17580..17798 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
NL714_RS23380 (NL714_23380) | 17800..18105 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
NL714_RS23385 (NL714_23385) | 18107..18397 | + | 291 | WP_001266176.1 | hypothetical protein | - |
NL714_RS23390 (NL714_23390) | 18394..18915 | + | 522 | WP_000198608.1 | hypothetical protein | - |
NL714_RS23395 (NL714_23395) | 18950..19732 | + | 783 | WP_000082169.1 | site-specific integrase | - |
NL714_RS23400 (NL714_23400) | 19741..20454 | + | 714 | WP_000545756.1 | EAL domain-containing protein | - |
NL714_RS23405 (NL714_23405) | 20479..20967 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
NL714_RS23410 (NL714_23410) | 20961..21446 | + | 486 | WP_000905606.1 | membrane protein | - |
NL714_RS23415 (NL714_23415) | 21723..22010 | - | 288 | WP_071530243.1 | hypothetical protein | - |
NL714_RS23420 (NL714_23420) | 22166..22726 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaTEM-1B | rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB | 1..64326 | 64326 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T251236 WP_001159863.1 NZ_CP100725:17800-18105 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | I3W3D5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A656ICA6 |