251233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4219277..4220058 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag NL714_RS20735 Protein ID WP_000626100.1
Coordinates 4219277..4219768 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NL714_RS20740 Protein ID WP_001110452.1
Coordinates 4219765..4220058 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS20700 (4214737) 4214737..4215084 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
NL714_RS20705 (4215060) 4215060..4216763 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
NL714_RS20710 (4216800) 4216800..4217375 + 576 WP_001188509.1 transcriptional regulator -
NL714_RS20720 (4217646) 4217646..4217720 - 75 Protein_4050 helix-turn-helix domain-containing protein -
NL714_RS20725 (4218100) 4218100..4218177 + 78 Protein_4051 porin family protein -
NL714_RS20730 (4218277) 4218277..4219029 + 753 WP_000842433.1 non-specific acid phosphatase -
NL714_RS20735 (4219277) 4219277..4219768 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
NL714_RS20740 (4219765) 4219765..4220058 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NL714_RS20745 (4220375) 4220375..4220596 + 222 WP_001576552.1 hypothetical protein -
NL714_RS20750 (4220862) 4220862..4221737 + 876 WP_000921676.1 AraC family transcriptional regulator -
NL714_RS20755 (4221734) 4221734..4222021 + 288 WP_001541332.1 transcriptional regulator RtsB -
NL714_RS20760 (4222014) 4222014..4222196 - 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
NL714_RS20765 (4222321) 4222321..4222569 + 249 Protein_4059 Ig-like domain-containing protein -
NL714_RS20770 (4222681) 4222681..4222812 + 132 Protein_4060 hypothetical protein -
NL714_RS20775 (4223106) 4223106..4224011 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T251233 WP_000626100.1 NZ_CP100724:c4219768-4219277 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251233 WP_001110452.1 NZ_CP100724:c4220058-4219765 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References