Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4112381..4112897 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag NL714_RS20160 Protein ID WP_000220582.1
Coordinates 4112381..4112665 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL714_RS20165 Protein ID WP_000212724.1
Coordinates 4112655..4112897 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS20145 (4107592) 4107592..4109244 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
NL714_RS20150 (4109653) 4109653..4111791 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL714_RS20155 (4111913) 4111913..4112377 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL714_RS20160 (4112381) 4112381..4112665 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL714_RS20165 (4112655) 4112655..4112897 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL714_RS20170 (4112975) 4112975..4114888 - 1914 WP_001212142.1 BglG family transcription antiterminator -
NL714_RS20175 (4114905) 4114905..4115645 - 741 WP_000779259.1 KDGP aldolase family protein -
NL714_RS20180 (4115642) 4115642..4116760 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL714_RS20185 (4116744) 4116744..4117877 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T251232 WP_000220582.1 NZ_CP100724:c4112665-4112381 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251232 WP_000212724.1 NZ_CP100724:c4112897-4112655 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References