251230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4027003..4027579 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NL714_RS19735 Protein ID WP_001131963.1
Coordinates 4027292..4027579 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NL714_RS19730 Protein ID WP_000063142.1
Coordinates 4027003..4027305 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS19715 (4023513) 4023513..4025663 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
NL714_RS19720 (4025758) 4025758..4025961 + 204 WP_000460616.1 YbdD/YjiX family protein -
NL714_RS19725 (4025972) 4025972..4026928 + 957 WP_000187843.1 GTPase -
NL714_RS19730 (4027003) 4027003..4027305 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NL714_RS19735 (4027292) 4027292..4027579 - 288 WP_001131963.1 BrnT family toxin Toxin
NL714_RS19740 (4027989) 4027989..4029245 + 1257 Protein_3859 NERD domain-containing protein/DEAD/DEAH box helicase -
NL714_RS19745 (4029239) 4029239..4029418 + 180 Protein_3860 DNA methyltransferase -
NL714_RS19750 (4029408) 4029408..4030712 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T251230 WP_001131963.1 NZ_CP100724:c4027579-4027292 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT251230 WP_000063142.1 NZ_CP100724:c4027305-4027003 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6PB01

References