Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 1887324..1887864 Replicon chromosome
Accession NC_015151
Organism Vulcanisaeta moutnovskia 768-28

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag VMUT_RS09915 Protein ID WP_013605282.1
Coordinates 1887553..1887864 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag VMUT_RS09910 Protein ID WP_013605281.1
Coordinates 1887324..1887551 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VMUT_RS13265 (VMUT_1912) 1882861..1882989 - 129 WP_013605275.1 hypothetical protein -
VMUT_RS09870 1883042..1883221 - 180 WP_048057019.1 aspartyl protease family protein -
VMUT_RS09875 1883328..1883780 + 453 WP_048057020.1 hypothetical protein -
VMUT_RS09880 (VMUT_1913) 1883736..1884326 - 591 WP_237699643.1 nucleotidyltransferase family protein -
VMUT_RS09885 (VMUT_1914) 1884319..1884780 - 462 WP_013605277.1 hypothetical protein -
VMUT_RS09890 1884840..1885142 - 303 WP_048057021.1 hypothetical protein -
VMUT_RS09895 (VMUT_1915) 1885288..1885902 + 615 WP_202795172.1 DedA family protein -
VMUT_RS09900 (VMUT_1916) 1885916..1886287 - 372 WP_013605279.1 hypothetical protein -
VMUT_RS09905 (VMUT_1917) 1886378..1887121 + 744 WP_013605280.1 hypothetical protein -
VMUT_RS09910 (VMUT_1918) 1887324..1887551 + 228 WP_013605281.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
VMUT_RS09915 (VMUT_1919) 1887553..1887864 + 312 WP_013605282.1 type II toxin-antitoxin system VapC family toxin Toxin
VMUT_RS12870 (VMUT_1920) 1888121..1888270 + 150 WP_013605283.1 hypothetical protein -
VMUT_RS12340 (VMUT_1921) 1888345..1888590 + 246 WP_013605284.1 ATP-binding protein -
VMUT_RS09925 (VMUT_1922) 1888706..1889239 - 534 WP_013605285.1 PaREP1 family protein -
VMUT_RS09930 (VMUT_1923) 1889261..1889506 - 246 WP_013605286.1 hypothetical protein -
VMUT_RS09935 (VMUT_1924) 1889608..1889802 - 195 WP_013605287.1 hypothetical protein -
VMUT_RS12875 1889846..1889992 - 147 WP_158304812.1 hypothetical protein -
VMUT_RS09940 (VMUT_1925) 1890522..1890845 + 324 WP_013605288.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
VMUT_RS09945 1890859..1891062 + 204 WP_048057022.1 hypothetical protein -
VMUT_RS09950 1891122..1891727 + 606 WP_048057023.1 hypothetical protein -
VMUT_RS09955 1891875..1892191 + 317 Protein_2022 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
VMUT_RS13270 1892260..1892394 + 135 WP_258167457.1 hypothetical protein -
VMUT_RS09960 1892469..1892684 + 216 WP_048057024.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(12-47)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12246.01 Da        Isoelectric Point: 4.5141

>T25123 WP_013605282.1 NC_015151:1887553-1887864 [Vulcanisaeta moutnovskia 768-28]
MSFVIDTNAIIAVISEDDVNHDKAVNIWNFDLRIINEILQDPKIKVIENNIQDIYFAIDHKDYIRHYDDFNDLIILSTAR
RLGLPLVTFDNELLELYHKFKWI

Download         Length: 312 bp

>T25123 NC_015151:1887553-1887864 [Vulcanisaeta moutnovskia 768-28]
ATGAGCTTCGTAATTGATACAAATGCTATTATAGCCGTAATCTCAGAGGATGACGTAAATCATGATAAGGCGGTGAACAT
TTGGAATTTTGACTTAAGAATCATAAATGAGATTTTACAAGACCCTAAAATTAAGGTTATTGAAAATAATATTCAGGACA
TTTATTTTGCCATTGATCATAAAGACTATATTAGGCATTATGACGACTTTAACGACTTAATAATACTTAGTACGGCACGG
AGATTAGGCTTACCACTAGTTACATTTGATAATGAATTACTAGAACTATACCATAAGTTTAAATGGATATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8850.65 Da        Isoelectric Point: 11.1659

>AT25123 WP_013605281.1 NC_015151:1887324-1887551 [Vulcanisaeta moutnovskia 768-28]
MRKQKLRGITKITIPALIRKRLGLKVGDTLIVRLEGDMIILEPKKRSITEIRIRLGRPIDWRYVEETIREEIGKE

Download         Length: 228 bp

>AT25123 NC_015151:1887324-1887551 [Vulcanisaeta moutnovskia 768-28]
TTGAGGAAACAAAAATTACGAGGAATTACCAAGATAACAATACCGGCACTTATTAGGAAGAGGCTTGGTTTAAAAGTTGG
GGACACGCTTATAGTTAGGCTCGAGGGTGATATGATCATTCTTGAACCAAAGAAGCGGAGCATTACGGAGATAAGGATCA
GGTTAGGAAGACCAATAGATTGGAGGTATGTTGAGGAGACCATAAGGGAGGAGATTGGTAAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References