Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3451473..3452093 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL714_RS17090 Protein ID WP_001280991.1
Coordinates 3451875..3452093 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL714_RS17085 Protein ID WP_000344807.1
Coordinates 3451473..3451847 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS17075 (3446612) 3446612..3447805 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL714_RS17080 (3447828) 3447828..3450977 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL714_RS17085 (3451473) 3451473..3451847 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL714_RS17090 (3451875) 3451875..3452093 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL714_RS17095 (3452272) 3452272..3452823 + 552 WP_001278793.1 maltose O-acetyltransferase -
NL714_RS17100 (3452941) 3452941..3453411 + 471 WP_000136183.1 YlaC family protein -
NL714_RS17105 (3453467) 3453467..3453607 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL714_RS17110 (3453613) 3453613..3453873 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL714_RS17115 (3454098) 3454098..3455648 + 1551 WP_000213140.1 EAL domain-containing protein -
NL714_RS17125 (3455879) 3455879..3456268 + 390 WP_000961287.1 MGMT family protein -
NL714_RS17130 (3456301) 3456301..3456870 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251227 WP_001280991.1 NZ_CP100724:3451875-3452093 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251227 WP_000344807.1 NZ_CP100724:3451473-3451847 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References