Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1028289..1029103 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL714_RS05005 Protein ID WP_000971655.1
Coordinates 1028289..1028816 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL714_RS05010 Protein ID WP_000855694.1
Coordinates 1028813..1029103 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS04965 (1023990) 1023990..1024424 - 435 WP_000429836.1 Hg(II)-responsive transcriptional regulator -
NL714_RS04970 (1024496) 1024496..1024846 + 351 WP_001294663.1 mercuric transport protein MerT -
NL714_RS04975 (1024860) 1024860..1025135 + 276 WP_065203552.1 mercury resistance system periplasmic binding protein MerP -
NL714_RS04980 (1025171) 1025171..1025593 + 423 WP_001340589.1 organomercurial transporter MerC -
NL714_RS04985 (1025772) 1025772..1026476 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
NL714_RS04990 (1026635) 1026635..1026751 + 117 Protein_978 hypothetical protein -
NL714_RS04995 (1026996) 1026996..1027652 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NL714_RS05000 (1028011) 1028011..1028216 + 206 Protein_980 IS5/IS1182 family transposase -
NL714_RS05005 (1028289) 1028289..1028816 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL714_RS05010 (1028813) 1028813..1029103 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL714_RS05015 (1029373) 1029373..1029562 - 190 Protein_983 IS3 family transposase -
NL714_RS05020 (1029966) 1029966..1030409 - 444 WP_000715097.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL714_RS05025 (1030865) 1030865..1031515 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
NL714_RS05030 (1031512) 1031512..1033200 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - invH 1016406..1030409 14003
- inside Prophage - invH / invF / invG 1010344..1033200 22856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251221 WP_000971655.1 NZ_CP100724:c1028816-1028289 [Salmonella enterica subsp. enterica serovar Enteritidis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251221 WP_000855694.1 NZ_CP100724:c1029103-1028813 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References