Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 915072..915732 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NL714_RS04355 Protein ID WP_000244756.1
Coordinates 915072..915485 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NL714_RS04360 Protein ID WP_000351186.1
Coordinates 915466..915732 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS04335 (911013) 911013..912746 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
NL714_RS04340 (912752) 912752..913465 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL714_RS04345 (913489) 913489..914385 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL714_RS04350 (914498) 914498..915019 + 522 WP_001055885.1 flavodoxin FldB -
NL714_RS04355 (915072) 915072..915485 - 414 WP_000244756.1 protein YgfX Toxin
NL714_RS04360 (915466) 915466..915732 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NL714_RS04365 (915982) 915982..916962 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NL714_RS04370 (917078) 917078..917737 - 660 WP_000250289.1 hemolysin III family protein -
NL714_RS04375 (917901) 917901..918212 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NL714_RS04380 (918370) 918370..919803 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251219 WP_000244756.1 NZ_CP100724:c915485-915072 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251219 WP_000351186.1 NZ_CP100724:c915732-915466 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References