251214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 8434..8960 Replicon plasmid pR17.4942_71k
Accession NZ_CP100720
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NL732_RS24595 Protein ID WP_000323025.1
Coordinates 8673..8960 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag NL732_RS24590 Protein ID WP_000534857.1
Coordinates 8434..8673 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS24560 (NL732_24560) 3602..4561 + 960 WP_000208728.1 DUF523 and DUF1722 domain-containing protein -
NL732_RS24565 (NL732_24565) 4707..5795 + 1089 WP_000633445.1 AAA family ATPase -
NL732_RS24570 (NL732_24570) 5858..6562 - 705 WP_001067852.1 IS6-like element IS26 family transposase -
NL732_RS24575 (NL732_24575) 6826..7899 - 1074 WP_000557466.1 hypothetical protein -
NL732_RS24580 (NL732_24580) 7943..8092 - 150 WP_000550473.1 hypothetical protein -
NL732_RS24585 (NL732_24585) 8299..8409 - 111 Protein_9 hypothetical protein -
NL732_RS24590 (NL732_24590) 8434..8673 + 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NL732_RS24595 (NL732_24595) 8673..8960 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NL732_RS24600 (NL732_24600) 9264..10046 - 783 Protein_12 IS21-like element ISSen3 family helper ATPase IstB -
NL732_RS24605 (NL732_24605) 10043..11065 - 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
NL732_RS24610 (NL732_24610) 11204..11428 + 225 Protein_14 hypothetical protein -
NL732_RS24615 (NL732_24615) 11865..13145 + 1281 WP_254521384.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / mph(A) / sul1 / qacE / aadA2 / dfrA12 / sul2 - 1..71243 71243
- inside IScluster/Tn tet(A) - 5858..21890 16032


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T251214 WP_000323025.1 NZ_CP100720:8673-8960 [Salmonella enterica subsp. enterica serovar Weltevreden]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9085.55 Da        Isoelectric Point: 4.6820

>AT251214 WP_000534857.1 NZ_CP100720:8434-8673 [Salmonella enterica subsp. enterica serovar Weltevreden]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References