Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 45516..46041 Replicon plasmid pR17.4942_82k
Accession NZ_CP100719
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name ccdB Uniprot ID A0A4V6H280
Locus tag NL732_RS24310 Protein ID WP_001159862.1
Coordinates 45736..46041 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A4U8C9U5
Locus tag NL732_RS24305 Protein ID WP_000813644.1
Coordinates 45516..45734 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS24295 (NL732_24295) 42177..43046 - 870 Protein_28 IS5 family transposase -
NL732_RS24300 (NL732_24300) 43626..44830 + 1205 WP_086011258.1 IS3 family transposase -
NL732_RS24305 (NL732_24305) 45516..45734 + 219 WP_000813644.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
NL732_RS24310 (NL732_24310) 45736..46041 + 306 WP_001159862.1 type II toxin-antitoxin system toxin CcdB Toxin
NL732_RS24315 (NL732_24315) 46099..46312 + 214 Protein_32 hypothetical protein -
NL732_RS24320 (NL732_24320) 46350..47132 + 783 WP_000083588.1 site-specific integrase -
NL732_RS24325 (NL732_24325) 47283..48224 - 942 WP_000728920.1 Rpn family recombination-promoting nuclease/putative transposase -
NL732_RS24330 (NL732_24330) 48650..49855 + 1206 WP_000427674.1 AAA family ATPase -
NL732_RS24335 (NL732_24335) 49855..50829 + 975 WP_000064273.1 ParB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81966 81966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11519.31 Da        Isoelectric Point: 5.8326

>T251213 WP_001159862.1 NZ_CP100719:45736-46041 [Salmonella enterica subsp. enterica serovar Weltevreden]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSDKVPRDLYPVMHIGDESYRLLTTDMASVPATVIGEEV
ADLSLQENDIRNAINLMFRGV

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8343.16 Da        Isoelectric Point: 4.4013

>AT251213 WP_000813644.1 NZ_CP100719:45516-45734 [Salmonella enterica subsp. enterica serovar Weltevreden]
MKQRITVTVDSDSYQLLREYDVNISGLVSTTMQNEARRLRAGRWQEENREGMAEVASFIEADGSFADENRNW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V6H280

Antitoxin

Source ID Structure
AlphaFold DB A0A4U8C9U5

References