Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/DUF1778(antitoxin) |
| Location | 13686..14443 | Replicon | plasmid pR17.4942_82k |
| Accession | NZ_CP100719 | ||
| Organism | Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A4U8I7M5 |
| Locus tag | NL732_RS24250 | Protein ID | WP_000406363.1 |
| Coordinates | 13961..14443 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A4U8I6Z6 |
| Locus tag | NL732_RS24245 | Protein ID | WP_001195099.1 |
| Coordinates | 13686..13970 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL732_RS24215 (NL732_24215) | 9909..10958 | + | 1050 | WP_001534988.1 | hypothetical protein | - |
| NL732_RS24220 (NL732_24220) | 11082..11267 | - | 186 | Protein_13 | resolvase | - |
| NL732_RS24225 (NL732_24225) | 11361..11555 | + | 195 | Protein_14 | DUF4158 domain-containing protein | - |
| NL732_RS24230 (NL732_24230) | 11892..12170 | + | 279 | WP_000534855.1 | colicin E3/pyocin S6 family cytotoxin | - |
| NL732_RS24235 (NL732_24235) | 12155..13117 | - | 963 | WP_000145248.1 | hypothetical protein | - |
| NL732_RS24240 (NL732_24240) | 13114..13374 | - | 261 | WP_000929810.1 | hypothetical protein | - |
| NL732_RS24245 (NL732_24245) | 13686..13970 | + | 285 | WP_001195099.1 | DUF1778 domain-containing protein | Antitoxin |
| NL732_RS24250 (NL732_24250) | 13961..14443 | + | 483 | WP_000406363.1 | GNAT family N-acetyltransferase | Toxin |
| NL732_RS24255 (NL732_24255) | 14448..14554 | - | 107 | Protein_20 | ethanolamine utilization protein EutE | - |
| NL732_RS24260 (NL732_24260) | 14827..15276 | + | 450 | WP_000750479.1 | hypothetical protein | - |
| NL732_RS24270 (NL732_24270) | 16643..17401 | + | 759 | WP_000493752.1 | 4'-phosphopantetheinyl transferase superfamily protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..81966 | 81966 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 18085.66 Da Isoelectric Point: 6.0789
>T251212 WP_000406363.1 NZ_CP100719:13961-14443 [Salmonella enterica subsp. enterica serovar Weltevreden]
MEISVTAPELLNEEHDLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPECTKRVVGYYSIATGSVSHDSLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDTVTRISNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPISPNILFYKI
MEISVTAPELLNEEHDLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPECTKRVVGYYSIATGSVSHDSLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDTVTRISNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPISPNILFYKI
Download Length: 483 bp
Antitoxin
Download Length: 95 a.a. Molecular weight: 10950.45 Da Isoelectric Point: 8.5309
>AT251212 WP_001195099.1 NZ_CP100719:13686-13970 [Salmonella enterica subsp. enterica serovar Weltevreden]
MQTTIRKSVRNNQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK
MQTTIRKSVRNNQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK
Download Length: 285 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4U8I7M5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4U8I6Z6 |