Detailed information of TA system TA025121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/-
• Location: 2480567..2482122
• Replicon: chromosome
• Accession: NC_015138
• Organism: Acidovorax avenae subsp. avenae ATCC 19860

Toxin (Protein)

• Gene name: avrRxo1
• Uniprot ID: -
• Locus tag: ACAV_RS10960
• Protein ID: WP_013594643.1
• Coordinates: 2480878..2482122 (-)
• Length: 415 a.a.

Antitoxin (Protein)

• Gene name: arc1
• Uniprot ID: F0QBG6
• Locus tag: ACAV_RS10955
• Protein ID: WP_013594642.1
• Coordinates: 2480567..2480863 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACAV_RS10945	2478749..2479546	+	798	WP_013594640.1	BMA_0021/BMA_0022 family TOMM bacteriocin	-
ACAV_RS10950	2479547..2480410	+	864	WP_041828723.1	class I SAM-dependent methyltransferase	-
ACAV_RS10955	2480567..2480863	-	297	WP_013594642.1	hypothetical protein	Antitoxin
ACAV_RS10960	2480878..2482122	-	1245	WP_013594643.1	zeta toxin family protein	Toxin
ACAV_RS10965	2482383..2484587	+	2205	WP_013594644.1	TOMM precursor leader peptide-binding protein	-
ACAV_RS10970	2484613..2485575	+	963	WP_013594645.1	FHA domain-containing protein	-
ACAV_RS10975	2485889..2486227	+	339	WP_013594646.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (145-284)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 415 a.a.
• Molecular weight: 44366.97 Da
• Isoelectric Point: 8.6817

>T25121 WP_013594643.1 NC_015138:c2482122-2480878 [Acidovorax avenae subsp. avenae ATCC 19860]
MTDRLSRRNSADSTPRPVTSNAASISRHETPPRPTSRPVHALPAGFPAPSQRSRSSSPSRVRASLPAKVPETSGNRPAIR
LPAAPRGSDEIFGLGELPPPGQSRWDYLAHPQNWRPERRQLHDRLIGDAKTAAQDFAEVIERGGHPPTLFALRGNTAAGK
TRMATQTIPVLANALKESGGAGCINPDIFKRSLAETPEGAKLTSAQVHAESCILADRLEDELRLQKTASGAAISMLVDKR
LAGAHEIDAYIKLAQQTGRKIELCDIDAPLEQSLMGVLQRKHEGDAPRPPYVAVANGFSAVRGHRLDVIDKFLSNPTLGS
YHLFGTTGNGSKAMVASVVNGELSIHDPQLYEAITDPQGARAGDSGDQIIDAALIDRLTKGIDDPARAMDARTALERYAG
MTWSDALAAHSSLT

Nucleotide

• Length: 1245 bp

>T25121 NC_015138:c2482122-2480878 [Acidovorax avenae subsp. avenae ATCC 19860]
ATGACAGACAGACTCAGCCGGCGAAATTCAGCGGATTCAACGCCCCGGCCCGTGACCAGCAACGCCGCTTCGATCAGCCG
GCATGAAACGCCACCGCGCCCGACCTCCCGTCCGGTACATGCGCTGCCAGCCGGCTTCCCGGCACCATCGCAGAGATCGC
GCAGTTCATCGCCTTCACGGGTCAGGGCCTCACTGCCGGCAAAAGTGCCGGAGACATCGGGCAACAGGCCTGCGATCCGT
TTGCCGGCCGCACCCAGGGGGTCGGACGAGATCTTCGGCCTGGGGGAACTCCCTCCTCCTGGCCAGTCCCGATGGGACTA
TTTGGCCCATCCTCAAAACTGGCGCCCCGAGCGGCGTCAATTGCATGACCGGCTGATCGGCGATGCGAAAACTGCAGCCC
AGGATTTCGCCGAGGTGATCGAGCGCGGTGGCCACCCACCGACATTGTTCGCGTTGCGAGGCAATACGGCTGCGGGAAAG
ACACGCATGGCGACACAAACCATCCCCGTACTCGCCAATGCCCTCAAGGAGAGTGGCGGCGCCGGCTGTATTAATCCCGA
CATCTTCAAACGTTCGCTCGCAGAAACTCCAGAGGGAGCAAAACTTACCTCGGCGCAGGTACACGCCGAGTCGTGCATCC
TCGCTGACCGGCTTGAAGACGAACTCCGATTGCAGAAGACCGCGAGCGGCGCGGCGATCAGCATGCTGGTCGATAAGCGA
CTGGCTGGAGCGCACGAAATCGACGCGTACATCAAGCTGGCTCAGCAGACCGGTCGCAAAATCGAGTTGTGCGATATTGA
TGCTCCACTCGAGCAGTCACTCATGGGCGTGCTGCAGCGCAAGCACGAAGGTGACGCCCCCCGGCCACCCTACGTTGCGG
TTGCCAACGGATTCTCGGCGGTTCGCGGGCACCGGCTCGATGTCATCGACAAGTTTCTCTCGAACCCGACCTTGGGGAGC
TATCATCTATTCGGCACTACCGGGAATGGCAGCAAGGCGATGGTTGCCAGCGTCGTCAACGGTGAACTGAGCATTCATGA
CCCTCAGTTATACGAGGCCATTACAGATCCCCAAGGTGCCCGGGCAGGCGATAGCGGCGATCAGATCATTGACGCTGCGC
TGATCGACCGGCTGACCAAAGGTATAGACGACCCAGCGCGAGCCATGGATGCCCGCACCGCATTGGAGCGGTACGCGGGC
ATGACGTGGTCGGACGCTCTGGCCGCCCATAGTTCACTGACTTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11194.69 Da
• Isoelectric Point: 7.1648

>AT25121 WP_013594642.1 NC_015138:c2480863-2480567 [Acidovorax avenae subsp. avenae ATCC 19860]
MTGLKGADALDFHKKLKERNAALRNAELNAAKELADKNGKEPFDLVKLERLCDTSQAGRLAEWNERQAMYEYMYYVEHKN
VGTLQDFARVVTTLASWS

Nucleotide

• Length: 297 bp

>AT25121 NC_015138:c2480863-2480567 [Acidovorax avenae subsp. avenae ATCC 19860]
ATGACAGGCCTGAAAGGCGCAGATGCGCTCGACTTCCATAAGAAACTCAAGGAACGCAATGCTGCTTTACGCAATGCGGA
GTTGAACGCGGCGAAGGAACTGGCCGACAAAAATGGCAAGGAGCCTTTTGATCTAGTGAAACTGGAGAGGCTTTGCGATA
CCAGTCAAGCAGGCCGCCTTGCTGAATGGAACGAACGGCAAGCCATGTACGAATACATGTATTACGTCGAGCACAAAAAT
GTTGGCACGTTGCAGGACTTCGCCCGGGTGGTGACAACGCTCGCGTCCTGGTCTTAA

Structures

Antitoxin

• AlphaFold DB: F0QBG6