251209

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4487850..4488631 Replicon chromosome
Accession NZ_CP100718
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag NL732_RS21905 Protein ID WP_000626100.1
Coordinates 4487850..4488341 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NL732_RS21910 Protein ID WP_001110452.1
Coordinates 4488338..4488631 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS21875 (4483856) 4483856..4484941 - 1086 WP_000099893.1 DNA cytosine methyltransferase -
NL732_RS21880 (4485111) 4485111..4485605 - 495 WP_000622310.1 GNAT family N-acetyltransferase -
NL732_RS21885 (4485602) 4485602..4485895 - 294 WP_001110462.1 DUF1778 domain-containing protein -
NL732_RS21890 (4486219) 4486219..4486263 - 45 WP_079827815.1 hypothetical protein -
NL732_RS21895 (4486673) 4486673..4486750 + 78 Protein_4287 porin family protein -
NL732_RS21900 (4486850) 4486850..4487602 + 753 WP_000842409.1 non-specific acid phosphatase -
NL732_RS21905 (4487850) 4487850..4488341 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
NL732_RS21910 (4488338) 4488338..4488631 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NL732_RS21915 (4488948) 4488948..4489169 + 222 WP_043991167.1 hypothetical protein -
NL732_RS21920 (4489430) 4489430..4490305 + 876 WP_000921676.1 AraC family transcriptional regulator -
NL732_RS21925 (4490302) 4490302..4490589 + 288 WP_001269916.1 transcriptional regulator RtsB -
NL732_RS21930 (4490565) 4490565..4490765 - 201 WP_001534538.1 ATP-binding cassette domain-containing protein -
NL732_RS21935 (4490785) 4490785..4490987 + 203 Protein_4295 hypothetical protein -
NL732_RS21940 (4490995) 4490995..4491262 + 268 Protein_4296 hypothetical protein -
NL732_RS21945 (4491557) 4491557..4492462 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4463797..4491177 27380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T251209 WP_000626100.1 NZ_CP100718:c4488341-4487850 [Salmonella enterica subsp. enterica serovar Weltevreden]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251209 WP_001110452.1 NZ_CP100718:c4488631-4488338 [Salmonella enterica subsp. enterica serovar Weltevreden]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References