251207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4336023..4336539 Replicon chromosome
Accession NZ_CP100718
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag NL732_RS21160 Protein ID WP_000220581.1
Coordinates 4336023..4336307 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL732_RS21165 Protein ID WP_000212724.1
Coordinates 4336297..4336539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS21145 (4331234) 4331234..4332886 + 1653 WP_000155038.1 alpha,alpha-phosphotrehalase -
NL732_RS21150 (4333295) 4333295..4335433 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL732_RS21155 (4335555) 4335555..4336019 + 465 WP_001268862.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL732_RS21160 (4336023) 4336023..4336307 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL732_RS21165 (4336297) 4336297..4336539 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL732_RS21170 (4336617) 4336617..4338530 - 1914 WP_001212140.1 BglG family transcription antiterminator -
NL732_RS21175 (4338547) 4338547..4339287 - 741 WP_000779255.1 KDGP aldolase family protein -
NL732_RS21180 (4339284) 4339284..4340402 - 1119 WP_001139192.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL732_RS21185 (4340386) 4340386..4341519 - 1134 WP_000459951.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T251207 WP_000220581.1 NZ_CP100718:c4336307-4336023 [Salmonella enterica subsp. enterica serovar Weltevreden]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251207 WP_000212724.1 NZ_CP100718:c4336539-4336297 [Salmonella enterica subsp. enterica serovar Weltevreden]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References