Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4282577..4283127 Replicon chromosome
Accession NZ_CP100718
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag NL732_RS20875 Protein ID WP_001199743.1
Coordinates 4282577..4282885 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag NL732_RS20880 Protein ID WP_000016244.1
Coordinates 4282888..4283127 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS20860 (4280059) 4280059..4280175 + 117 Protein_4085 transposase -
NL732_RS20865 (4280401) 4280401..4281420 - 1020 WP_001023050.1 IS110 family transposase -
NL732_RS20870 (4281487) 4281487..4282453 + 967 Protein_4087 IS3 family transposase -
NL732_RS20875 (4282577) 4282577..4282885 - 309 WP_001199743.1 CcdB family protein Toxin
NL732_RS20880 (4282888) 4282888..4283127 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NL732_RS20885 (4283240) 4283240..4283488 - 249 WP_000254752.1 ribbon-helix-helix domain-containing protein -
NL732_RS20890 (4283565) 4283565..4283720 - 156 Protein_4091 DUF4942 domain-containing protein -
NL732_RS20895 (4283711) 4283711..4284572 - 862 Protein_4092 IS630 family transposase -
NL732_RS20900 (4285350) 4285350..4286375 + 1026 WP_000369883.1 phage portal protein -
NL732_RS20905 (4286403) 4286403..4288073 - 1671 WP_000368629.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4280401..4296722 16321
- inside IScluster/Tn - - 4280059..4284527 4468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T251206 WP_001199743.1 NZ_CP100718:c4282885-4282577 [Salmonella enterica subsp. enterica serovar Weltevreden]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT251206 WP_000016244.1 NZ_CP100718:c4283127-4282888 [Salmonella enterica subsp. enterica serovar Weltevreden]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References