251205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4231542..4232118 Replicon chromosome
Accession NZ_CP100718
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NL732_RS20670 Protein ID WP_001131963.1
Coordinates 4231831..4232118 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag NL732_RS20665 Protein ID WP_000063143.1
Coordinates 4231542..4231844 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS20650 (4228053) 4228053..4230203 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
NL732_RS20655 (4230298) 4230298..4230501 + 204 WP_000460616.1 YbdD/YjiX family protein -
NL732_RS20660 (4230512) 4230512..4231468 + 957 WP_000187837.1 GTPase -
NL732_RS20665 (4231542) 4231542..4231844 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
NL732_RS20670 (4231831) 4231831..4232118 - 288 WP_001131963.1 BrnT family toxin Toxin
NL732_RS20675 (4232387) 4232387..4233301 - 915 WP_000290515.1 restriction endonuclease -
NL732_RS20680 (4233499) 4233499..4237008 + 3510 WP_001043490.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T251205 WP_001131963.1 NZ_CP100718:c4232118-4231831 [Salmonella enterica subsp. enterica serovar Weltevreden]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT251205 WP_000063143.1 NZ_CP100718:c4231844-4231542 [Salmonella enterica subsp. enterica serovar Weltevreden]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References