251197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2395421..2395943 Replicon chromosome
Accession NZ_CP100718
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NL732_RS11755 Protein ID WP_000221343.1
Coordinates 2395421..2395705 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag NL732_RS11760 Protein ID WP_000885426.1
Coordinates 2395695..2395943 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL732_RS11730 (2390981) 2390981..2392222 - 1242 WP_001095731.1 MFS transporter -
NL732_RS11735 (2392212) 2392212..2393720 - 1509 WP_000199407.1 FAD-dependent oxidoreductase -
NL732_RS11740 (2393765) 2393765..2394253 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
NL732_RS11745 (2394446) 2394446..2395093 + 648 Protein_2299 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL732_RS11750 (2395089) 2395089..2395250 - 162 Protein_2300 RidA family protein -
NL732_RS11755 (2395421) 2395421..2395705 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL732_RS11760 (2395695) 2395695..2395943 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL732_RS11765 (2396095) 2396095..2396214 + 120 Protein_2303 type II and III secretion system -
NL732_RS11770 (2396300) 2396300..2396632 + 333 WP_000253078.1 DUF1493 family protein -
NL732_RS11775 (2396921) 2396921..2397202 - 282 WP_000742000.1 hypothetical protein -
NL732_RS11780 (2397504) 2397504..2398970 - 1467 WP_000987828.1 hypothetical protein -
NL732_RS11785 (2399228) 2399228..2400235 + 1008 WP_000201070.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251197 WP_000221343.1 NZ_CP100718:c2395705-2395421 [Salmonella enterica subsp. enterica serovar Weltevreden]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT251197 WP_000885426.1 NZ_CP100718:c2395943-2395695 [Salmonella enterica subsp. enterica serovar Weltevreden]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References