251189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4397521..4398302 Replicon chromosome
Accession NZ_CP100715
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.5474

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NL730_RS21605 Protein ID WP_000626099.1
Coordinates 4397521..4398012 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NL730_RS21610 Protein ID WP_001110452.1
Coordinates 4398009..4398302 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL730_RS21565 (4392707) 4392707..4392949 - 243 WP_197603740.1 hypothetical protein -
NL730_RS21570 (4392946) 4392946..4393302 - 357 WP_033567083.1 hypothetical protein -
NL730_RS21575 (4393299) 4393299..4394171 - 873 WP_033567082.1 ParA family protein -
NL730_RS21580 (4394362) 4394362..4394439 - 78 Protein_4221 helix-turn-helix domain-containing protein -
NL730_RS21585 (4394530) 4394530..4394862 - 333 WP_001165471.1 MerR family transcriptional regulator -
NL730_RS21590 (4394934) 4394934..4395311 + 378 WP_000916345.1 EthD family reductase -
NL730_RS21595 (4396344) 4396344..4396418 + 75 Protein_4224 porin family protein -
NL730_RS21600 (4396521) 4396521..4397273 + 753 WP_000842434.1 non-specific acid phosphatase -
NL730_RS21605 (4397521) 4397521..4398012 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NL730_RS21610 (4398009) 4398009..4398302 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NL730_RS21615 (4398619) 4398619..4398840 + 222 WP_001576552.1 hypothetical protein -
NL730_RS21620 (4399105) 4399105..4399980 + 876 WP_000921674.1 AraC family transcriptional regulator -
NL730_RS21625 (4399977) 4399977..4400264 + 288 WP_001269916.1 transcriptional regulator RtsB -
NL730_RS21630 (4400287) 4400287..4400502 + 216 WP_001595136.1 hypothetical protein -
NL730_RS21635 (4400510) 4400510..4400779 + 270 WP_010989096.1 hypothetical protein -
NL730_RS21640 (4401073) 4401073..4401978 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T251189 WP_000626099.1 NZ_CP100715:c4398012-4397521 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251189 WP_001110452.1 NZ_CP100715:c4398302-4398009 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References