Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3472929..3473549 Replicon chromosome
Accession NZ_CP100715
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.5474

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL730_RS17220 Protein ID WP_001280991.1
Coordinates 3473331..3473549 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL730_RS17215 Protein ID WP_000344807.1
Coordinates 3472929..3473303 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL730_RS17205 (3468068) 3468068..3469261 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL730_RS17210 (3469284) 3469284..3472433 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL730_RS17215 (3472929) 3472929..3473303 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL730_RS17220 (3473331) 3473331..3473549 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL730_RS17225 (3473728) 3473728..3474279 + 552 WP_001278792.1 maltose O-acetyltransferase -
NL730_RS17230 (3474396) 3474396..3474866 + 471 WP_000136181.1 YlaC family protein -
NL730_RS17235 (3474922) 3474922..3475062 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL730_RS17240 (3475068) 3475068..3475328 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL730_RS17245 (3475553) 3475553..3477103 + 1551 WP_000213139.1 EAL domain-containing protein -
NL730_RS17255 (3477334) 3477334..3477723 + 390 WP_000961285.1 MGMT family protein -
NL730_RS17260 (3477756) 3477756..3478325 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251184 WP_001280991.1 NZ_CP100715:3473331-3473549 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251184 WP_000344807.1 NZ_CP100715:3472929-3473303 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References