251164

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3515363..3515983 Replicon chromosome
Accession NZ_CP100710
Organism Salmonella enterica subsp. enterica serovar Blockley strain R18.0186

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL733_RS17385 Protein ID WP_001280991.1
Coordinates 3515765..3515983 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL733_RS17380 Protein ID WP_000344807.1
Coordinates 3515363..3515737 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL733_RS17370 (3510502) 3510502..3511695 + 1194 WP_001039200.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL733_RS17375 (3511718) 3511718..3514867 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL733_RS17380 (3515363) 3515363..3515737 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL733_RS17385 (3515765) 3515765..3515983 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL733_RS17390 (3516161) 3516161..3516712 + 552 WP_064047028.1 maltose O-acetyltransferase -
NL733_RS17395 (3516829) 3516829..3517299 + 471 WP_000136181.1 YlaC family protein -
NL733_RS17400 (3517355) 3517355..3517495 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL733_RS17405 (3517501) 3517501..3517761 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL733_RS17410 (3517986) 3517986..3519536 + 1551 WP_000213139.1 EAL domain-containing protein -
NL733_RS17420 (3519767) 3519767..3520156 + 390 WP_000961285.1 MGMT family protein -
NL733_RS17425 (3520211) 3520211..3520780 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251164 WP_001280991.1 NZ_CP100710:3515765-3515983 [Salmonella enterica subsp. enterica serovar Blockley]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251164 WP_000344807.1 NZ_CP100710:3515363-3515737 [Salmonella enterica subsp. enterica serovar Blockley]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References