Detailed information of TA system TA025116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3939782..3940683
• Replicon: chromosome
• Accession: NC_015064
• Organism: Granulicella tundricola MP5ACTX9

Toxin (Protein)

• Gene name: PrcT
• Uniprot ID: E8X3E6
• Locus tag: ACIX9_RS17160
• Protein ID: WP_013581758.1
• Coordinates: 3939782..3940228 (-)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ACIX9_RS17165
• Protein ID: WP_041597188.1
• Coordinates: 3940231..3940683 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACIX9_RS17140	3935090..3935503	+	414	WP_041597187.1	hypothetical protein	-
ACIX9_RS24950	3935500..3936132	+	633	WP_013581755.1	nucleotidyltransferase domain-containing protein	-
ACIX9_RS17150	3936429..3936707	-	279	WP_013581756.1	oxidative damage protection protein	-
ACIX9_RS17155	3936848..3939733	-	2886	WP_013581757.1	RNB domain-containing ribonuclease	-
ACIX9_RS17160	3939782..3940228	-	447	WP_013581758.1	RES family NAD+ phosphorylase	Toxin
ACIX9_RS17165	3940231..3940683	-	453	WP_041597188.1	DUF2384 domain-containing protein	Antitoxin
ACIX9_RS17170	3940752..3941927	-	1176	WP_013581760.1	acyltransferase	-
ACIX9_RS17175	3941975..3942805	-	831	WP_013581761.1	hypothetical protein	-
ACIX9_RS17180	3942883..3944301	-	1419	WP_041597189.1	NAD(P)/FAD-dependent oxidoreductase	-
ACIX9_RS26520	3944383..3944583	+	201	WP_041597913.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-134)

Antitoxin

• Antitoxin Xre (58-150)

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 16903.36 Da
• Isoelectric Point: 7.3583

>T25116 WP_013581758.1 NC_015064:c3940228-3939782 [Granulicella tundricola MP5ACTX9]
MLFWRISNYATLDGAGGLYVSGRWHTRGRPVVYCTWHPSTALLETLVHLEIDAEDRPANFQLLRIESPKGLSLERLEESG
LPANWRADPTATQRQGDAWLASRRTLLLEVPSALLPETWNLIVNPLHPQAPELRITKIYNRPFDPRLI

Nucleotide

• Length: 447 bp

>T25116 NC_015064:c3940228-3939782 [Granulicella tundricola MP5ACTX9]
ATGCTTTTCTGGCGCATCAGCAACTACGCCACGCTCGATGGTGCCGGCGGCCTCTATGTCTCCGGCCGGTGGCACACGCG
CGGACGTCCGGTCGTCTACTGCACATGGCACCCGTCCACCGCGCTGCTTGAAACGCTTGTCCACCTGGAGATCGACGCGG
AAGATCGTCCGGCCAACTTTCAACTCCTCCGCATCGAATCCCCTAAAGGCCTCTCGCTTGAACGTCTCGAAGAGTCAGGG
CTCCCAGCCAACTGGCGTGCAGATCCCACCGCGACCCAGCGGCAGGGCGACGCATGGCTGGCCTCTCGACGCACTCTACT
GCTCGAAGTTCCCAGCGCCCTCCTGCCTGAAACCTGGAACCTGATCGTCAACCCGCTACACCCACAAGCGCCGGAGCTTC
GGATTACCAAGATTTACAACCGGCCTTTCGATCCGCGGCTCATCTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 17198.72 Da
• Isoelectric Point: 8.5723

>AT25116 WP_041597188.1 NC_015064:c3940683-3940231 [Granulicella tundricola MP5ACTX9]
MMTVQAIPQRQPAVFYRRLESKLGVSPLDSDRDIARFVEARLPLTSVDALSSHGITTEEIYDYILPRRTLVHRRTRHEAL
THEESDRAVRLARIASLAEEVFGEDAKAARWLRKPKTRFEGRTPLELLRTEAGARLIEEMLLQLDFGFAA

Nucleotide

• Length: 453 bp

>AT25116 NC_015064:c3940683-3940231 [Granulicella tundricola MP5ACTX9]
ATGATGACCGTCCAAGCCATTCCGCAGCGCCAGCCCGCCGTCTTCTATCGCCGCCTGGAGTCCAAGCTGGGCGTCAGTCC
GCTGGACTCAGATCGGGATATTGCCCGCTTCGTCGAGGCCCGCCTGCCCCTGACCTCGGTCGACGCACTCTCCAGCCATG
GCATCACCACGGAGGAGATTTACGACTACATCCTCCCACGCCGAACCCTCGTGCATCGCCGCACCCGCCATGAGGCCCTC
ACGCATGAGGAATCGGACCGGGCCGTCCGTCTGGCACGCATCGCTTCCCTGGCTGAGGAGGTCTTCGGAGAAGATGCAAA
GGCCGCACGCTGGCTTCGTAAGCCCAAAACCCGCTTTGAAGGAAGAACACCCCTGGAGCTCCTGCGTACCGAGGCCGGCG
CACGCCTGATCGAAGAGATGCTGCTCCAACTCGATTTTGGCTTCGCCGCCTAG

Structures

Toxin

• AlphaFold DB: E8X3E6