251158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1041272..1042086 Replicon chromosome
Accession NZ_CP100710
Organism Salmonella enterica subsp. enterica serovar Blockley strain R18.0186

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A627ECG4
Locus tag NL733_RS05020 Protein ID WP_064047347.1
Coordinates 1041272..1041799 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL733_RS05025 Protein ID WP_000855694.1
Coordinates 1041796..1042086 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL733_RS04990 (1037572) 1037572..1037970 + 399 Protein_979 cytoplasmic protein -
NL733_RS04995 (1038161) 1038161..1038400 + 240 Protein_980 hypothetical protein -
NL733_RS05000 (1038557) 1038557..1039225 + 669 WP_000445914.1 hypothetical protein -
NL733_RS05005 (1039252) 1039252..1039746 + 495 WP_000424947.1 hypothetical protein -
NL733_RS05010 (1039991) 1039991..1040647 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
NL733_RS05015 (1040976) 1040976..1041199 + 224 Protein_984 IS5/IS1182 family transposase -
NL733_RS05020 (1041272) 1041272..1041799 - 528 WP_064047347.1 GNAT family N-acetyltransferase Toxin
NL733_RS05025 (1041796) 1041796..1042086 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL733_RS05030 (1042356) 1042356..1042545 - 190 Protein_987 IS3 family transposase -
NL733_RS05035 (1042786) 1042786..1043112 + 327 WP_000393302.1 hypothetical protein -
NL733_RS05040 (1043385) 1043385..1043732 - 348 WP_001669174.1 DUF1493 family protein -
NL733_RS05045 (1043717) 1043717..1044166 - 450 WP_000381612.1 membrane protein -
NL733_RS05050 (1044598) 1044598..1045041 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL733_RS05055 (1045497) 1045497..1046147 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1041023..1041199 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-147)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19171.01 Da        Isoelectric Point: 9.6420

>T251158 WP_064047347.1 NZ_CP100710:c1041799-1041272 [Salmonella enterica subsp. enterica serovar Blockley]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLWRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQACDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251158 WP_000855694.1 NZ_CP100710:c1042086-1041796 [Salmonella enterica subsp. enterica serovar Blockley]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A627ECG4

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References