Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 85422..87045 Replicon plasmid pR18.0409_279k
Accession NZ_CP100708
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NL735_RS24765 Protein ID WP_000088046.1
Coordinates 85720..87045 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NL735_RS24760 Protein ID WP_024136327.1
Coordinates 85422..85715 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS24735 (NL735_24735) 81294..82535 + 1242 WP_001053338.1 VWA domain-containing protein -
NL735_RS24740 (NL735_24740) 83098..83379 - 282 WP_000077926.1 hypothetical protein -
NL735_RS24745 (NL735_24745) 83429..83620 - 192 WP_000398480.1 hypothetical protein -
NL735_RS24750 (NL735_24750) 83712..84053 - 342 WP_001151575.1 hypothetical protein -
NL735_RS24755 (NL735_24755) 84426..84818 + 393 WP_000341066.1 hypothetical protein -
NL735_RS24760 (NL735_24760) 85422..85715 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NL735_RS24765 (NL735_24765) 85720..87045 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NL735_RS24770 (NL735_24770) 87106..87312 + 207 WP_000134171.1 hypothetical protein -
NL735_RS24775 (NL735_24775) 87414..87824 + 411 WP_000985911.1 hypothetical protein -
NL735_RS24780 (NL735_24780) 87837..88652 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
NL735_RS24785 (NL735_24785) 88906..89331 + 426 WP_001043843.1 hypothetical protein -
NL735_RS24790 (NL735_24790) 89785..90021 + 237 Protein_85 type I restriction-modification system subunit M N-terminal domain-containing protein -
NL735_RS24795 (NL735_24795) 90076..90375 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-IIa / aph(6)-Ic / ant(3'')-Ia / lnu(F) / sul3 / cmlA1 / aadA2 / blaTEM-1B / tet(A) / dfrA12 / qacE / sul1 / mph(A) / aac(3)-IVa / aph(4)-Ia / floR / oqxB / oqxA - 1..278879 278879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T251147 WP_000088046.1 NZ_CP100708:85720-87045 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT251147 WP_024136327.1 NZ_CP100708:85422-85715 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References