251144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4404738..4405519 Replicon chromosome
Accession NZ_CP100707
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NL735_RS21655 Protein ID WP_000626099.1
Coordinates 4404738..4405229 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NL735_RS21660 Protein ID WP_001110452.1
Coordinates 4405226..4405519 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS21615 (4399924) 4399924..4400166 - 243 WP_197603740.1 hypothetical protein -
NL735_RS21620 (4400163) 4400163..4400519 - 357 WP_033567083.1 hypothetical protein -
NL735_RS21625 (4400516) 4400516..4401388 - 873 WP_033567082.1 ParA family protein -
NL735_RS21630 (4401579) 4401579..4401656 - 78 Protein_4231 helix-turn-helix domain-containing protein -
NL735_RS21635 (4401747) 4401747..4402079 - 333 WP_001165471.1 MerR family transcriptional regulator -
NL735_RS21640 (4402151) 4402151..4402528 + 378 WP_000916345.1 EthD family reductase -
NL735_RS21645 (4403561) 4403561..4403635 + 75 Protein_4234 porin family protein -
NL735_RS21650 (4403738) 4403738..4404490 + 753 WP_000842434.1 non-specific acid phosphatase -
NL735_RS21655 (4404738) 4404738..4405229 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NL735_RS21660 (4405226) 4405226..4405519 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NL735_RS21665 (4405836) 4405836..4406057 + 222 WP_001576552.1 hypothetical protein -
NL735_RS21670 (4406322) 4406322..4407197 + 876 WP_000921674.1 AraC family transcriptional regulator -
NL735_RS21675 (4407194) 4407194..4407481 + 288 WP_001269916.1 transcriptional regulator RtsB -
NL735_RS21680 (4407504) 4407504..4407719 + 216 WP_001595136.1 hypothetical protein -
NL735_RS21685 (4407727) 4407727..4407996 + 270 WP_010989096.1 hypothetical protein -
NL735_RS21690 (4408290) 4408290..4409195 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T251144 WP_000626099.1 NZ_CP100707:c4405229-4404738 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251144 WP_001110452.1 NZ_CP100707:c4405519-4405226 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References