Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4194660..4195176 Replicon chromosome
Accession NZ_CP100707
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NL735_RS20550 Protein ID WP_000220578.1
Coordinates 4194660..4194944 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL735_RS20555 Protein ID WP_000212724.1
Coordinates 4194934..4195176 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS20535 (4189872) 4189872..4191524 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NL735_RS20540 (4191933) 4191933..4194071 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL735_RS20545 (4194192) 4194192..4194656 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL735_RS20550 (4194660) 4194660..4194944 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL735_RS20555 (4194934) 4194934..4195176 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL735_RS20560 (4195254) 4195254..4197167 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NL735_RS20565 (4197184) 4197184..4197924 - 741 WP_000779263.1 KDGP aldolase family protein -
NL735_RS20570 (4197921) 4197921..4199039 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL735_RS20575 (4199023) 4199023..4200156 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T251143 WP_000220578.1 NZ_CP100707:c4194944-4194660 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251143 WP_000212724.1 NZ_CP100707:c4195176-4194934 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References