251139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3481485..3482105 Replicon chromosome
Accession NZ_CP100707
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.0409

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL735_RS17275 Protein ID WP_001280991.1
Coordinates 3481887..3482105 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL735_RS17270 Protein ID WP_000344807.1
Coordinates 3481485..3481859 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL735_RS17260 (3476624) 3476624..3477817 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL735_RS17265 (3477840) 3477840..3480989 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL735_RS17270 (3481485) 3481485..3481859 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL735_RS17275 (3481887) 3481887..3482105 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL735_RS17280 (3482284) 3482284..3482835 + 552 WP_001278792.1 maltose O-acetyltransferase -
NL735_RS17285 (3482952) 3482952..3483422 + 471 WP_000136181.1 YlaC family protein -
NL735_RS17290 (3483478) 3483478..3483618 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL735_RS17295 (3483624) 3483624..3483884 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL735_RS17300 (3484109) 3484109..3485659 + 1551 WP_000213139.1 EAL domain-containing protein -
NL735_RS17310 (3485890) 3485890..3486279 + 390 WP_000961285.1 MGMT family protein -
NL735_RS17315 (3486312) 3486312..3486881 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251139 WP_001280991.1 NZ_CP100707:3481887-3482105 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251139 WP_000344807.1 NZ_CP100707:3481485-3481859 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References