Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 118094..118830 Replicon plasmid pRAHAQ02
Accession NC_015063
Organism Rahnella sp. Y9602

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3FK99
Locus tag RAHAQ_RS26480 Protein ID WP_013578407.1
Coordinates 118094..118573 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A0H3FHR6
Locus tag RAHAQ_RS25670 Protein ID WP_013578408.1
Coordinates 118570..118830 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RAHAQ_RS26470 113898..114033 - 136 Protein_108 transposase -
RAHAQ_RS25655 114127..114660 - 534 WP_013578402.1 thioredoxin fold domain-containing protein -
RAHAQ_RS26615 115084..115302 - 219 WP_148232237.1 hypothetical protein -
RAHAQ_RS26960 115429..115792 - 364 Protein_111 GGDEF domain-containing protein -
RAHAQ_RS26475 116114..116380 - 267 WP_013578404.1 Txe/YoeB family addiction module toxin -
RAHAQ_RS25660 116377..116622 - 246 WP_013578405.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RAHAQ_RS25665 116953..118002 + 1050 WP_041689277.1 tyrosine-type recombinase/integrase -
RAHAQ_RS26480 118094..118573 - 480 WP_013578407.1 GNAT family N-acetyltransferase Toxin
RAHAQ_RS25670 118570..118830 - 261 WP_013578408.1 DUF1778 domain-containing protein Antitoxin
RAHAQ_RS26620 118923..119165 + 243 Protein_117 serine recombinase -
RAHAQ_RS25675 119724..120332 - 609 WP_013578409.1 CPBP family intramembrane metalloprotease -
RAHAQ_RS25680 120401..121732 - 1332 Protein_119 peptidase domain-containing ABC transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..133486 133486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-147)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17367.07 Da        Isoelectric Point: 9.5460

>T25113 WP_013578407.1 NC_015063:c118573-118094 [Rahnella sp. Y9602]
MSLQLSAPEPLTTAHILDAFGCGETTLDEWLKRRALTNHLNGASRTFVVTAHDKSVFGYYALAAGAVSHREAPGAVRRNM
PDPIPVIVLGRLAVDLRTQGVKLGSSLLQDAVLRVRSIAENTGVRALLIHALHEPAKQFYEHYGFTSSPINPMTLMLRL

Download         Length: 480 bp

>T25113 NC_015063:c118573-118094 [Rahnella sp. Y9602]
ATGAGTTTACAATTGTCTGCTCCTGAGCCACTTACAACTGCACATATCCTTGATGCTTTCGGTTGTGGGGAAACAACATT
AGATGAATGGTTAAAACGGCGCGCTCTGACAAACCACTTAAACGGTGCAAGTCGCACTTTTGTTGTCACGGCTCACGATA
AAAGTGTTTTTGGTTATTATGCACTCGCTGCCGGTGCTGTGTCGCACAGGGAAGCCCCAGGGGCTGTTCGGCGTAATATG
CCTGATCCTATTCCGGTCATAGTATTGGGAAGACTGGCGGTCGACCTTCGCACTCAAGGAGTAAAGTTAGGTTCATCATT
GCTACAGGATGCCGTTCTTCGAGTTCGCTCAATTGCTGAAAACACAGGGGTCAGAGCATTGCTCATACATGCACTTCATG
AACCGGCTAAACAATTTTATGAACACTACGGTTTTACATCATCGCCAATTAATCCGATGACATTAATGCTACGCCTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9714.13 Da        Isoelectric Point: 4.5388

>AT25113 WP_013578408.1 NC_015063:c118830-118570 [Rahnella sp. Y9602]
MRDAAINLRALPEQRDLIDQAASLLGKNRSDFMLEVACERAQAILLDQVFFQLDTEKFHEFTAILDAPQNANQGLERLMA
VKAPWA

Download         Length: 261 bp

>AT25113 NC_015063:c118830-118570 [Rahnella sp. Y9602]
ATGCGTGACGCTGCGATTAATTTGCGTGCTTTGCCAGAACAACGTGATCTCATAGATCAAGCCGCCAGCCTATTAGGTAA
AAACCGATCTGATTTTATGCTGGAAGTAGCGTGTGAGCGCGCACAGGCTATTCTGCTCGACCAAGTTTTTTTCCAGTTAG
ATACTGAAAAATTTCATGAATTCACAGCGATACTTGACGCACCTCAAAATGCAAATCAAGGTCTGGAACGTCTGATGGCA
GTTAAAGCGCCTTGGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FK99

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FHR6

References