251123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1949..2496 Replicon plasmid pR18.0872_93k
Accession NZ_CP100704
Organism Salmonella enterica subsp. enterica serovar Thompson strain R18.0872

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag NL734_RS24160 Protein ID WP_001384452.1
Coordinates 2218..2496 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID W0FTF6
Locus tag NL734_RS24155 Protein ID WP_000079942.1
Coordinates 1949..2218 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL734_RS24150 (1) 1..1032 + 1032 WP_022630251.1 plasmid replication initiator RepA -
NL734_RS24155 (1949) 1949..2218 + 270 WP_000079942.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NL734_RS24160 (2218) 2218..2496 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
NL734_RS24165 (2542) 2542..2754 + 213 Protein_3 3'-5' exonuclease -
NL734_RS24170 (3013) 3013..3942 - 930 WP_000102288.1 hypothetical protein -
NL734_RS24175 (4379) 4379..5566 - 1188 WP_001697863.1 IS91 family transposase -
NL734_RS24180 (5566) 5566..5931 - 366 WP_000124134.1 hypothetical protein -
NL734_RS24185 (6079) 6079..7371 - 1293 Protein_7 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 - 1..93173 93173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T251123 WP_001384452.1 NZ_CP100704:2218-2496 [Salmonella enterica subsp. enterica serovar Thompson]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10282.61 Da        Isoelectric Point: 7.2057

>AT251123 WP_000079942.1 NZ_CP100704:1949-2218 [Salmonella enterica subsp. enterica serovar Thompson]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A140JYS5

References