251119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4122962..4123478 Replicon chromosome
Accession NZ_CP100702
Organism Salmonella enterica subsp. enterica serovar Thompson strain R18.0872

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NL734_RS20240 Protein ID WP_000220578.1
Coordinates 4122962..4123246 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL734_RS20245 Protein ID WP_000212724.1
Coordinates 4123236..4123478 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL734_RS20225 (4118078) 4118078..4119730 + 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -
NL734_RS20230 (4120139) 4120139..4122277 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
NL734_RS20235 (4122494) 4122494..4122958 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL734_RS20240 (4122962) 4122962..4123246 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL734_RS20245 (4123236) 4123236..4123478 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL734_RS20250 (4123556) 4123556..4125469 - 1914 WP_001212135.1 BglG family transcription antiterminator -
NL734_RS20255 (4125486) 4125486..4126226 - 741 WP_023193113.1 KDGP aldolase family protein -
NL734_RS20260 (4126223) 4126223..4127341 - 1119 WP_017465839.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL734_RS20265 (4127325) 4127325..4128458 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T251119 WP_000220578.1 NZ_CP100702:c4123246-4122962 [Salmonella enterica subsp. enterica serovar Thompson]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251119 WP_000212724.1 NZ_CP100702:c4123478-4123236 [Salmonella enterica subsp. enterica serovar Thompson]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References