Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3413000..3413620 Replicon chromosome
Accession NZ_CP100702
Organism Salmonella enterica subsp. enterica serovar Thompson strain R18.0872

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL734_RS16930 Protein ID WP_001280991.1
Coordinates 3413402..3413620 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL734_RS16925 Protein ID WP_000344807.1
Coordinates 3413000..3413374 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL734_RS16915 (3408139) 3408139..3409332 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL734_RS16920 (3409355) 3409355..3412504 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL734_RS16925 (3413000) 3413000..3413374 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL734_RS16930 (3413402) 3413402..3413620 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL734_RS16935 (3413799) 3413799..3414350 + 552 WP_001278793.1 maltose O-acetyltransferase -
NL734_RS16940 (3414468) 3414468..3414938 + 471 WP_000136183.1 YlaC family protein -
NL734_RS16945 (3414994) 3414994..3415134 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL734_RS16950 (3415140) 3415140..3415400 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL734_RS16955 (3415625) 3415625..3417175 + 1551 WP_000213139.1 EAL domain-containing protein -
NL734_RS16965 (3417406) 3417406..3417795 + 390 WP_000961285.1 MGMT family protein -
NL734_RS16970 (3417828) 3417828..3418397 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251116 WP_001280991.1 NZ_CP100702:3413402-3413620 [Salmonella enterica subsp. enterica serovar Thompson]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251116 WP_000344807.1 NZ_CP100702:3413000-3413374 [Salmonella enterica subsp. enterica serovar Thompson]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References