251115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2317964..2318486 Replicon chromosome
Accession NZ_CP100702
Organism Salmonella enterica subsp. enterica serovar Thompson strain R18.0872

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NL734_RS11295 Protein ID WP_000221343.1
Coordinates 2318202..2318486 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL734_RS11290 Protein ID WP_000885424.1
Coordinates 2317964..2318212 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL734_RS11270 (2313685) 2313685..2314692 - 1008 WP_000201074.1 LacI family DNA-binding transcriptional regulator -
NL734_RS11275 (2314950) 2314950..2316416 + 1467 WP_000987828.1 hypothetical protein -
NL734_RS11280 (2316718) 2316718..2317008 + 291 WP_000742001.1 hypothetical protein -
NL734_RS11285 (2317361) 2317361..2317816 + 456 Protein_2204 helix-turn-helix domain-containing protein -
NL734_RS11290 (2317964) 2317964..2318212 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL734_RS11295 (2318202) 2318202..2318486 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL734_RS11300 (2318657) 2318657..2319046 + 390 WP_000194089.1 RidA family protein -
NL734_RS11305 (2319098) 2319098..2320177 - 1080 WP_017465711.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL734_RS11310 (2320370) 2320370..2320858 - 489 WP_017465710.1 MarR family winged helix-turn-helix transcriptional regulator -
NL734_RS11315 (2320903) 2320903..2322411 + 1509 WP_017465709.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2314953..2325268 10315


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T251115 WP_000221343.1 NZ_CP100702:2318202-2318486 [Salmonella enterica subsp. enterica serovar Thompson]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT251115 WP_000885424.1 NZ_CP100702:2317964-2318212 [Salmonella enterica subsp. enterica serovar Thompson]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References