Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1002271..1003085 Replicon chromosome
Accession NZ_CP100702
Organism Salmonella enterica subsp. enterica serovar Thompson strain R18.0872

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NL734_RS04785 Protein ID WP_000971655.1
Coordinates 1002271..1002798 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NL734_RS04790 Protein ID WP_000855694.1
Coordinates 1002795..1003085 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL734_RS04755 (998481) 998481..998879 + 399 Protein_930 cytoplasmic protein -
NL734_RS04760 (999070) 999070..999309 + 240 Protein_931 hypothetical protein -
NL734_RS04765 (999466) 999466..1000134 + 669 WP_000445914.1 hypothetical protein -
NL734_RS04770 (1000161) 1000161..1000655 + 495 WP_000424947.1 hypothetical protein -
NL734_RS04775 (1000900) 1000900..1001556 - 657 WP_001748710.1 protein-serine/threonine phosphatase -
NL734_RS04780 (1001789) 1001789..1002198 + 410 Protein_935 IS5/IS1182 family transposase -
NL734_RS04785 (1002271) 1002271..1002798 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NL734_RS04790 (1002795) 1002795..1003085 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NL734_RS04795 (1003355) 1003355..1003533 - 179 Protein_938 IS3 family transposase -
NL734_RS04800 (1003774) 1003774..1004100 + 327 WP_000393302.1 hypothetical protein -
NL734_RS04805 (1004373) 1004373..1004720 - 348 WP_023198553.1 DUF1493 family protein -
NL734_RS04810 (1004705) 1004705..1005154 - 450 WP_000381612.1 membrane protein -
NL734_RS04815 (1005585) 1005585..1006028 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NL734_RS04820 (1006484) 1006484..1007134 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1002058..1002198 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251110 WP_000971655.1 NZ_CP100702:c1002798-1002271 [Salmonella enterica subsp. enterica serovar Thompson]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251110 WP_000855694.1 NZ_CP100702:c1003085-1002795 [Salmonella enterica subsp. enterica serovar Thompson]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References