Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 23884..24386 Replicon plasmid pRAHAQ02
Accession NC_015063
Organism Rahnella sp. Y9602

Toxin (Protein)


Gene name relB Uniprot ID A0A0H3FHL0
Locus tag RAHAQ_RS25250 Protein ID WP_013578329.1
Coordinates 23884..24144 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0H3FIR1
Locus tag RAHAQ_RS25255 Protein ID WP_013578330.1
Coordinates 24141..24386 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RAHAQ_RS25225 19749..19982 - 234 WP_013578325.1 hypothetical protein -
RAHAQ_RS25230 20020..20415 - 396 WP_013578326.1 plasmid partitioning/stability family protein -
RAHAQ_RS27135 20434..20757 - 324 WP_052300791.1 hypothetical protein -
RAHAQ_RS27140 20928..21137 - 210 WP_193784879.1 hypothetical protein -
RAHAQ_RS25240 21381..22346 - 966 WP_013578327.1 ParB/RepB/Spo0J family partition protein -
RAHAQ_RS25245 22355..23554 - 1200 WP_013578328.1 AAA family ATPase -
RAHAQ_RS25250 23884..24144 - 261 WP_013578329.1 Txe/YoeB family addiction module toxin Toxin
RAHAQ_RS25255 24141..24386 - 246 WP_013578330.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RAHAQ_RS25260 24801..25808 - 1008 WP_013578331.1 replication initiation protein -
RAHAQ_RS25265 26737..27372 + 636 WP_013578332.1 AAA family ATPase -
RAHAQ_RS25270 27366..27626 + 261 WP_013578333.1 hypothetical protein -
RAHAQ_RS25275 27841..28632 - 792 WP_013578334.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..133486 133486
- flank IS/Tn - - 18636..19640 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10385.06 Da        Isoelectric Point: 10.2948

>T25111 WP_013578329.1 NC_015063:c24144-23884 [Rahnella sp. Y9602]
MKTVFTPRAAEDYRYWQENDPKKFERVRQLIKAVHTDAFVGIGKPEPLKHKRPLWSRRIDREHRLVYYVKDGEVIIIACR
FHYTGI

Download         Length: 261 bp

>T25111 NC_015063:c24144-23884 [Rahnella sp. Y9602]
ATGAAAACGGTATTCACGCCGCGTGCAGCTGAGGATTATCGATATTGGCAGGAAAATGACCCAAAAAAGTTTGAGCGCGT
CCGACAGCTGATTAAAGCCGTGCATACTGACGCGTTCGTTGGGATAGGCAAACCAGAACCATTGAAGCATAAAAGACCAT
TGTGGTCGCGGCGTATCGACCGGGAACACCGGCTTGTCTACTACGTAAAGGACGGCGAAGTTATTATCATCGCATGTCGC
TTCCATTACACCGGAATCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8948.88 Da        Isoelectric Point: 4.0057

>AT25111 WP_013578330.1 NC_015063:c24386-24141 [Rahnella sp. Y9602]
MRHITFTEARTNFANILNQVSDDADTVVITRRGSRDVVMLDADEYSSMVETLYLFSNPANAAHIEASLAQLDSGDTVEID
V

Download         Length: 246 bp

>AT25111 NC_015063:c24386-24141 [Rahnella sp. Y9602]
ATGCGACATATCACTTTTACAGAAGCCCGCACCAATTTCGCGAATATACTGAATCAGGTCAGTGATGACGCGGATACAGT
AGTTATTACCCGTCGTGGTAGCCGTGACGTCGTGATGCTCGACGCAGACGAATACAGCAGCATGGTTGAGACGCTTTACC
TTTTCAGTAATCCTGCGAACGCTGCACATATAGAGGCATCATTAGCCCAGTTGGATAGTGGTGATACGGTAGAAATTGAT
GTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FHL0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FIR1

References