251108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834531..835191 Replicon chromosome
Accession NZ_CP100702
Organism Salmonella enterica subsp. enterica serovar Thompson strain R18.0872

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NL734_RS04015 Protein ID WP_000244756.1
Coordinates 834778..835191 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NL734_RS04010 Protein ID WP_000351186.1
Coordinates 834531..834797 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL734_RS03990 (830458) 830458..831891 - 1434 WP_017465472.1 6-phospho-beta-glucosidase BglA -
NL734_RS03995 (832050) 832050..832361 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NL734_RS04000 (832526) 832526..833185 + 660 WP_254521170.1 hemolysin III family protein -
NL734_RS04005 (833301) 833301..834281 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
NL734_RS04010 (834531) 834531..834797 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NL734_RS04015 (834778) 834778..835191 + 414 WP_000244756.1 protein YgfX Toxin
NL734_RS04020 (835244) 835244..835765 - 522 WP_001055885.1 flavodoxin FldB -
NL734_RS04025 (835878) 835878..836774 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL734_RS04030 (836798) 836798..837511 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL734_RS04035 (837517) 837517..839250 + 1734 WP_017465473.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251108 WP_000244756.1 NZ_CP100702:834778-835191 [Salmonella enterica subsp. enterica serovar Thompson]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251108 WP_000351186.1 NZ_CP100702:834531-834797 [Salmonella enterica subsp. enterica serovar Thompson]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References