Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4042087..4043725 Replicon chromosome
Accession NZ_CP100698
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.2256

Toxin (Protein)


Gene name hipA Uniprot ID B5F4A8
Locus tag NL710_RS19460 Protein ID WP_001255026.1
Coordinates 4042087..4043415 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B5F4A7
Locus tag NL710_RS19465 Protein ID WP_001099274.1
Coordinates 4043420..4043725 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL710_RS19440 (4037625) 4037625..4038608 + 984 WP_000210270.1 toll/interleukin-1 receptor domain-containing protein -
NL710_RS19445 (4038877) 4038877..4039404 - 528 WP_001043245.1 hypothetical protein -
NL710_RS19450 (4039401) 4039401..4040597 - 1197 WP_000542997.1 hypothetical protein -
NL710_RS19455 (4040786) 4040786..4041775 - 990 WP_077905772.1 restriction endonuclease -
NL710_RS19460 (4042087) 4042087..4043415 - 1329 WP_001255026.1 type II toxin-antitoxin system HipA family toxin Toxin
NL710_RS19465 (4043420) 4043420..4043725 - 306 WP_001099274.1 helix-turn-helix transcriptional regulator Antitoxin
NL710_RS19470 (4044472) 4044472..4044942 + 471 WP_001222753.1 hypothetical protein -
NL710_RS19480 (4046480) 4046480..4046716 + 237 WP_001748005.1 conjugal transfer protein TraG N-terminal domain-containing protein -
NL710_RS19485 (4046833) 4046833..4048221 - 1389 WP_254522760.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage fosA7 - 4028201..4072066 43865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50786.57 Da        Isoelectric Point: 5.0474

>T251099 WP_001255026.1 NZ_CP100698:c4043415-4042087 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11362.04 Da        Isoelectric Point: 9.7765

>AT251099 WP_001099274.1 NZ_CP100698:c4043725-4043420 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4S6F6

Antitoxin

Source ID Structure
AlphaFold DB A0A3V5VUF2

References