Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3428406..3429026 Replicon chromosome
Accession NZ_CP100698
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.2256

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL710_RS16615 Protein ID WP_001280991.1
Coordinates 3428808..3429026 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL710_RS16610 Protein ID WP_000344807.1
Coordinates 3428406..3428780 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL710_RS16600 (3423545) 3423545..3424738 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL710_RS16605 (3424761) 3424761..3427910 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL710_RS16610 (3428406) 3428406..3428780 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL710_RS16615 (3428808) 3428808..3429026 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL710_RS16620 (3429205) 3429205..3429756 + 552 WP_001278793.1 maltose O-acetyltransferase -
NL710_RS16625 (3429874) 3429874..3430344 + 471 WP_000136183.1 YlaC family protein -
NL710_RS16630 (3430400) 3430400..3430540 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL710_RS16635 (3430546) 3430546..3430806 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL710_RS16640 (3431031) 3431031..3432581 + 1551 WP_000213148.1 EAL domain-containing protein -
NL710_RS16650 (3432812) 3432812..3433201 + 390 WP_000961286.1 MGMT family protein -
NL710_RS16655 (3433234) 3433234..3433803 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251096 WP_001280991.1 NZ_CP100698:3428808-3429026 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251096 WP_000344807.1 NZ_CP100698:3428406-3428780 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References