Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 2352513..2353035 | Replicon | chromosome |
Accession | NZ_CP100698 | ||
Organism | Salmonella enterica subsp. enterica serovar Agona strain R18.2256 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | B5F5Y5 |
Locus tag | NL710_RS11400 | Protein ID | WP_000221343.1 |
Coordinates | 2352513..2352797 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | V1H457 |
Locus tag | NL710_RS11405 | Protein ID | WP_000885424.1 |
Coordinates | 2352787..2353035 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NL710_RS11380 (2348588) | 2348588..2350096 | - | 1509 | WP_000199409.1 | FAD-dependent oxidoreductase | - |
NL710_RS11385 (2350141) | 2350141..2350629 | + | 489 | WP_001293635.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
NL710_RS11390 (2350822) | 2350822..2351901 | + | 1080 | WP_000954697.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
NL710_RS11395 (2351953) | 2351953..2352342 | - | 390 | WP_000194089.1 | RidA family protein | - |
NL710_RS11400 (2352513) | 2352513..2352797 | - | 285 | WP_000221343.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
NL710_RS11405 (2352787) | 2352787..2353035 | - | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
NL710_RS11410 (2353448) | 2353448..2353801 | - | 354 | WP_000418733.1 | hypothetical protein | - |
NL710_RS11415 (2353804) | 2353804..2354193 | - | 390 | WP_001044696.1 | hypothetical protein | - |
NL710_RS11420 (2354558) | 2354558..2354665 | + | 108 | Protein_2235 | IS110 family transposase | - |
NL710_RS11425 (2355081) | 2355081..2355413 | + | 333 | WP_000253156.1 | DUF1493 family protein | - |
NL710_RS11430 (2355688) | 2355688..2355876 | - | 189 | WP_001276021.1 | DUF29 family protein | - |
NL710_RS11435 (2356289) | 2356289..2357197 | + | 909 | WP_001176641.1 | LysR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2350822..2360069 | 9247 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11075.85 Da Isoelectric Point: 10.6500
>T251090 WP_000221343.1 NZ_CP100698:c2352797-2352513 [Salmonella enterica subsp. enterica serovar Agona]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
Download Length: 285 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5H5JSW4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I0WPN5 |