Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 8434..8960 Replicon plasmid pR18.0830_78k
Accession NZ_CP100697
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NL711_RS24445 Protein ID WP_000323025.1
Coordinates 8673..8960 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag NL711_RS24440 Protein ID WP_000534857.1
Coordinates 8434..8673 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS24410 (NL711_24410) 3602..4561 + 960 WP_000208728.1 DUF523 and DUF1722 domain-containing protein -
NL711_RS24415 (NL711_24415) 4707..5795 + 1089 WP_000633445.1 AAA family ATPase -
NL711_RS24420 (NL711_24420) 5858..6562 - 705 WP_001067852.1 IS6-like element IS26 family transposase -
NL711_RS24425 (NL711_24425) 6826..7899 - 1074 WP_000557466.1 hypothetical protein -
NL711_RS24430 (NL711_24430) 7943..8092 - 150 WP_000550473.1 hypothetical protein -
NL711_RS24435 (NL711_24435) 8299..8409 - 111 Protein_9 hypothetical protein -
NL711_RS24440 (NL711_24440) 8434..8673 + 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NL711_RS24445 (NL711_24445) 8673..8960 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NL711_RS24450 (NL711_24450) 9264..10046 - 783 Protein_12 IS21-like element ISSen3 family helper ATPase IstB -
NL711_RS24455 (NL711_24455) 10043..11065 - 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
NL711_RS24460 (NL711_24460) 11204..11428 + 225 Protein_14 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / aph(3')-Ia / mph(A) / sul1 / qacE / aadA2 / dfrA12 / sul2 - 1..78306 78306
- inside IScluster/Tn - - 5858..11065 5207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T251086 WP_000323025.1 NZ_CP100697:8673-8960 [Salmonella enterica subsp. enterica serovar Weltevreden]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9085.55 Da        Isoelectric Point: 4.6820

>AT251086 WP_000534857.1 NZ_CP100697:8434-8673 [Salmonella enterica subsp. enterica serovar Weltevreden]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References